Peter Hortschansky

Dr. Peter Hortschansky

Molecular and Applied Microbiology

Phone: +49 3641 532-1085 Fax: +49 3641 532-0802 Email: peter.hortschansky@leibniz-hki.de

Topics
Publications

Misslinger M†, Scheven MT†, Hortschansky P, Sanchez Lopez-Berges M, Heiss K, Beckmann N, Heigl T, Hermann M, Krüger T, Kniemeyer O, Brakhage AA*, Haas H* †shared first authors, *corresponding authors (2019) The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus. PLoS Genetics 15(9), e1008379. Details PubMed

Dasari P, Shopova IA, Stroe M, Wartenberg D, Dahse HM, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF (2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635. Details PubMed Open Access PDF Supplement

Hoefgen S, Lin J, Fricke J, Stroe MC, Mattern DJ, Kufs JE, Hortschansky P, Brakhage AA, Hoffmeister D, Valiante V (2018) Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi. Metab Eng 48, 44-51. Details PubMed Open Access

Long N, Orasch T, Zhang S, Gao L, Xu X, Hortschansky P, Ye J, Zhang F, Xu K, Gsaller F, Straßburger M, Binder U, Heinekamp T, Brakhage AA, Haas H, Lu L (2018) The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus. PLoS Genet 14(10), e1007762. Details PubMed

Voltersen V, Blango M, Herrmann S, Schmidt F, Heinekamp T, Strassburger M, Krüger T, Bacher P, Lother J, Weiss E, Hünniger K, Liu H, Hortschansky P, Scheffold A, Loeffler J, Krappmann S, Nietzsche S, Kurzai O, Einsele H, Kniemeyer O, Filler S, Reichard U, Brakhage AA (2018) Proteome analysis reveals the conidial surface protein CcpA essential for virulence of the pathogenic fungus Aspergillus fumigatus. MBio 9(5), e01557-18. Details PubMed

Bergfeld A, Dasari P, Werner S, Hughes TR, Song WC, Hortschansky P, Brakhage AA, Hünig T, Zipfel PF, Beyersdorf N (2017) Direct Binding of the pH-Regulated Protein 1 (Pra1) from Candida albicans Inhibits Cytokine Secretion by Mouse CD4(+) T Cells. Front Microbiol 8, 844. Details PubMed

Gunnella F, Kunisch E, Bungartz M, Maenz S, Horbert V, Xin L, Mika J, Borowski J, Bischoff S, Schubert H, Hortschansky P, Sachse A, Illerhaus B, Günster J, Bossert J, Jandt KD, Plöger F, Kinne RW, Brinkmann O (2017) Low-dose BMP-2 is sufficient to enhance the bone formation induced by an injectable, PLGA fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia. Spine J 17(11), 1699-1711. Details PubMed

Hortschansky P, Haas H, Huber EM, Groll M, Brakhage AA (2017) The CCAAT-binding complex (CBC) in Aspergillus species. Biochim Biophys Acta 1860(5), 560-570. (Review) Details PubMed

Misslinger M, Gsaller F, Hortschansky P, Müller C, Bracher F, Bromley MJ, Haas H (2017) The cytochrome b5 CybE is regulated by iron availability and is crucial for azole resistance in A. fumigatus. Metallomics 9(11), 1655-1665. Details PubMed

Alborzinia H, Shaikhkarami M, Hortschansky P, Wölfl S (2016) BMP2 Transfer to Neighboring Cells and Activation of Signaling. Traffic 17(9), 1042-1053. Details PubMed

Gsaller F, Hortschansky P, Furukawa T, Carr PD, Rash B, Capilla J, Müller C, Bracher F, Bowyer P, Haas H, Brakhage AA, Bromley MJ (2016) Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex. PLOS Pathog 12(7), e1005775. Details PubMed

Kröber A, Scherlach K, Hortschansky P, Shelest E, Staib P, Kniemeyer O, Brakhage AA (2016) HapX Mediates Iron Homeostasis in the Pathogenic Dermatophyte Arthroderma benhamiae but Is Dispensable for Virulence. PLOS ONE 11(3), e0150701. Details PubMed

Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Löffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O (2016) Proteomic profiling of serological responses to Aspergillus fumigatus antigens in patients with invasive aspergillosis. J Proteome Res 15(5), 1580-1591. Details PubMed

Valiante V, Baldin C, Hortschansky P, Jain R, Thywißen A, Straßburger M, Shelest E, Heinekamp T, Brakhage AA (2016) The Aspergillus fumigatus conidial melanin production is regulated by the bifunctional bHLH DevR and MADS-box RlmA transcription factors. Mol Microbiol 102(2), 321-335. Details PubMed

Gallmetzer A, Silvestrini L, Schinko T, Gesslbauer B, Hortschansky P, Dattenböck C, Muro-Pastor MI, Kungl A, Brakhage AA, Scazzocchio C, Strauss J (2015) Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA. PLOS Genet 11(7), e1005297. Details PubMed Open Access

Gressler M, Hortschansky P, Geib E, Brock M (2015) A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster. Front Microbiol 6, 184. Details PubMed

Gressler M, Meyer F, Heine D, Hortschansky P, Hertweck C, Brock M (2015) Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals. eLife 4, e07861. Details PubMed Open Access PDF

Hortschansky P, Ando E, Tuppatsch K, Arikawa H, Kobayashi T, Kato M, Haas H, Brakhage AA (2015) Deciphering the combinatorial DNA-binding code of the CCAAT-binding complex and the iron-regulatory basic region leucine zipper (bZIP) transcription factor HapX. J Biol Chem 290(10), 6058-6070. Details PubMed

Gsaller F, Hortschansky P, Beattie SR, Klammer V, Tuppatsch K, Lechner BE, Rietzschel N, Werner ER, Vogan AA, Chung D, Mühlenhoff U, Kato M, Cramer RA, Brakhage AA, Haas H (2014) The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess. EMBO J 33(19), 2261-2276. Details PubMed

Alborzinia H, Schmidt-Glenewinkel H, Ilkavets I, Breitkopf-Heinlein K, Cheng X, Hortschansky P, Dooley S, Wölfl S (2013) Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists. J Cell Sci 126(Pt 1), 117-127. Details PubMed

Eberhardt HU, Buhlmann D, Hortschansky P, Chen Q, Böhm S, Kemper MJ, Wallich R, Hartmann A, Hallström T, Zipfel PF, Skerka C (2013) Human factor H-related protein 2 (CFHR2) regulates complement activation. PLOS One 8(11), e78617. Details PubMed

Mischo A, Ohlenschläger O, Hortschansky P, Ramachandran R, Görlach M (2013) Structural insights into a wildtype domain of the oncoprotein E6 and its interaction with a PDZ domain. PLOS One 8(4), e62584-e62584. Details PubMed

Huber EM, Scharf DH, Hortschansky P, Groll M, Brakhage AA (2012) DNA minor groove sensing and widening by the CCAAT-binding complex. Structure 20(10), 1757-1768. Details PubMed

Linde J, Hortschansky P, Fazius E, Brakhage AA, Guthke R, Haas H (2012) Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol 6, 6. Details PubMed

Morgado I, Wieligmann K, Bereza M, Rönicke R, Meinhardt K, Annamalai K, Baumann M, Wacker J, Hortschansky P, Malešević M, Parthier C, Mawrin C, Schiene-Fischer C, Reymann KG, Stubbs MT, Balbach J, Görlach M, Horn U, Fändrich M (2012) Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment. Proc Natl Acad Sci U S A 109(31), 12503-12508. Details PubMed Open Access PDF

Ohlenschläger O, Kuhnert A, Schneider A, Haumann S, Bellstedt P, Keller H, Saluz HP, Hortschansky P, Hänel F, Grosse F, Görlach M, Pospiech H (2012) The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif. Nucleic Acids Res 40(17), 8309-8324. Details PubMed

Scharf DH, Heinekamp T, Remme N, Hortschansky P, Brakhage AA, Hertweck C (2012) Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Appl Microbiol Biotechnol 93(2), 467-472. Details PubMed

Haupt C, Bereza M, Kumar ST, Kieninger B, Morgado I, Hortschansky P, Fritz G, Röcken C, Horn U, Fändrich M (2011) Pattern recognition with a fibril-specific antibody fragment reveals the surface variability of natural amyloid fibrils. J Mol Biol 408(3), 529-540. Details PubMed

Haupt C, Morgado I, Kumar ST, Parthier C, Bereza M, Hortschansky P, Stubbs MT, Horn U, Fändrich M (2011) Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions. J Mol Biol 405(2), 341-348. Details PubMed

Scharf DH, Remme N, Habel A, Chankhamjon P, Scherlach K, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C (2011) A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc 133(32), 12322-12325. Details PubMed

Scharf DH, Remme N, Heinekamp T, Hortschansky P, Brakhage AA, Hertweck C (2010) Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus. J Am Chem Soc 132(29), 10136-10141. Details PubMed

Thön M, Al Abdallah Q, Hortschansky P, Scharf DH, Eisendle M, Haas H, Brakhage AA (2010) The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res 38(4), 1098-1113. Details PubMed

Brakhage AA, Thön M, Spröte P, Scharf DH, Al-Abdallah Q, Wolke SM, Hortschansky P (2009) Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors. Phytochemistry 70(15-16), 1801-1811. Details PubMed

Spröte P, Hynes MJ, Hortschansky P, Shelest E, Scharf DH, Wolke SM, Brakhage AA (2008) Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster. Mol Microbiol 70(2), 445-461. Details PubMed

Hortschansky P, Eisendle M, Al-Abdallah Q, Schmidt AD, Bergmann S, Thön M, Kniemeyer O, Abt B, Seeber B, Werner ER, Kato M, Brakhage AA, Haas H (2007) Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron. EMBO J 26(13), 3157-3168. Details PubMed

Thön M, Al-Abdallah Q, Hortschansky P, Brakhage AA (2007) The thioredoxin system of the filamentous fungus Aspergillus nidulans: impact on development and oxidative stress response. J Biol Chem 282(37), 27259-27269. Details PubMed