Daniel Heine

Daniel Heine

Biomolecular Chemistry

Publications

Dörfer M, Heine D, König S, Gore S, Werz O, Hertweck C, Gressler M, Hoffmeister D (2019) Melleolides impact fungal translation via elongation factor 2. Org Biomol Chem 17(19), 4906-4916. Details PubMed

Heine D, Holmes NA, Worsley SF, Santos ACA, Innocent TM, Scherlach K, Patrick EH, Yu DW, Murrell JC, Vieria PC, Boomsma JJ, Hertweck C, Hutchings MI, Wilkinson B (2018) Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen. Nat Commun 9(1), 2208. Details PubMed Open Access

Sundaram S, Kim HJ, Bauer R, Thongkongkaew T, Heine D, Hertweck C (2018) On-line polyketide cyclization into diverse medium-sized lactones by a specialized ketosynthase domain. Angew Chem Int Ed 57(35), 11223-11227. Details PubMed

Heine D, Sundaram S, Beudert M, Martin K, Hertweck C (2016) A widespread bacterial phenazine forms conjugates with biogenic thiols and crosslinks proteins. Chem Sci 7, 4848-4855. Details PDF

Ueberschaar N, Heine D, Hertweck C (2016) Zinc(II)-Assisted Aryl-Finkelstein-Reaction for the Synthesis of Aryl Iodides. Synlett 27, 1794-1797. Details Open Access

Wick J, Heine D, Lackner G, Misiek M, Tauber J, Jagusch H, Hertweck C, Hoffmeister D (2016) A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (honey mushroom) toxins. Appl Environ Microbiol 82, 1196-1204. Details PubMed Open Access

Braesel J, Götze S, Shah F, Heine D, Tauber J, Hertweck C, Tunlid A, Stallforth P, Hoffmeister D (2015) Three redundant synthetases secure redox-active pigment production in the basidiomycete Paxillus involutus. Chem Biol 22, 1325-1334. Details PubMed

Gressler M, Meyer F, Heine D, Hortschansky P, Hertweck C, Brock M (2015) Phytotoxin production in Aspergillus terreus is regulated by independent environmental signals. eLife 4, e07861. Details PubMed Open Access PDF

Heine D, Sundaram S, Bretschneider T, Hertweck C (2015) Twofold polyketide branching by a stereoselective enzymatic Michael addition Chem Commun (Camb). 51(48), 9872-9875. Details PubMed

Sundaram S, Heine D, Hertweck C (2015) Polyketide synthase chimeras reveal key role of ketosynthase domain in chain branching Nat Chem Biol. 11(12), 949-951. Details PubMed

Zocher G, Vilstrup J, Heine D, Hallab A, Goralski E, Hertweck C, Stahl M, Schäberle TF, Stehle T (2015) Structural basis of head to head polyketide fusion by CorB. Chem Sci 6(11), 6525-6536. Details

Heine D, Bretschneider T, Sundaram S, Hertweck C (2014) Enzymatic Polyketide Chain Branching to Give Substituted Lactone, Lactam, and Glutarimide Heterocycles. Angew Chem Int Ed Engl 53(43), 11645-11649. Details PubMed

Heine D, Martin K, Hertweck C (2014) Genomics-guided discovery of endophenazines from Kitasatospora sp. HKI 714. J Nat Prod 77(4), 1083-1087. Details PubMed

Bretschneider T, Heim JB, Heine D, Winkler R, Busch B, Kusebauch B, Stehle T, Zocher G, Hertweck C (2013) Vinylogous chain branching catalysed by a dedicated polyketide synthase module. Nature 502(7469), 124-128. Details PubMed