Sandra Höfgen

Dr. Sandra Höfgen

Biobricks of Microbial Natural Product Syntheses

Phone: +49 3641 532-1726 Fax: +49 3641 532-2726 Email: sandra.hoefgen@leibniz-hki.de

Topics
Publications

Manfiolli AO, Siqueira FS, Dos Reis TF, Van Dijck P, Schrevens S, Hoefgen S, Föge M, Straßburger M, de Assis LJ, Heinekamp T, Rocha MC, Janevska S, Brakhage AA, Malavazi I, Goldman GH, Valiante V (2019) Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus. MBio 10(2), pii: e00215-19. Details PubMed Open Access

Hoefgen S, Lin J, Fricke J, Stroe MC, Mattern DJ, Kufs JE, Hortschansky P, Brakhage AA, Hoffmeister D, Valiante V (2018) Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi. Metab Eng 48, 44-51. Details PubMed Open Access

Hoefgen S, Dahms SO, Oertwig K, Than ME (2015) The amyloid precursor protein shows a pH-dependent conformational switch in its E1 domain. J Mol Biol 427(2), 433-442. Details PubMed

Coburger I, Hoefgen S, Than ME (2014) The structural biology of the amyloid precursor protein APP - a complex puzzle reveals its multi-domain architecture. Biol Chem 395(5), 485-498. Details PubMed

Hoefgen S, Coburger I, Roeser D, Schaub Y, Dahms SO, Than ME (2014) Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain. J Struct Biol 187(1), 30-37. Details PubMed

Honarmand Ebrahimi K, Dienemann C, Hoefgen S, Than ME, Hagedoorn PL, Hagen WR (2013) The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain. PLOS One 8(8), e72177. Details PubMed

Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME (2010) Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein. Proc Natl Acad Sci U S A 107(12), 5381-5386. Details PubMed