- Biochemical and genetic basis of fungal natural product biosyntheses
- Natural products of basidiomycetes and Ralstonia solanacearum
- Microbial nonribosomal peptide synthetases
|2014-||Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena|
|2009-2014||Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena|
|2007-2009||Assistant professor (tenure track) University of Minnesota, Saint Paul, MN, USA|
|2008||Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg|
|2004-2007||Research assistant, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg|
|2002-2004||Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship)|
|2002||Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg|
|1998||Diploma in biology at the Eberhard-Karls-University, Tübingen|
Awards · Appointments · Scientific Activities
|Since 2016||Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena|
|2013-2016||Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM).|
|Since 2011||Member of the editorial board of various journals|
(2019) Diketopiperazine Formation in Gliotoxin Biosynthesis Requires Dedicated Cyclization and Thiolation Domains. Angew Chem Int Ed 58(41), 14589-14593.
(2019) A genomics perspective on natural product biosynthesis in plant pathogenic bacteria Nat Prod Rep 36(2), 307-325. (Review)
(2019) Simultaneous production of psilocybin and a cocktail of β-carboline monoamine oxidase inhibitors in ‘magic’ mushrooms. Chem Eur J [Accepted]
(2019) S-Adenosyl-L-Methionin Salvage Impacts Psilocybin Formation in 'Magic' Mushrooms ChemBioChem [Accepted]
(2019) Diversity and bioactivity of Armillaria sesquiterpene aryl ester natural products. Mycol Prog 18(8), 1027-1037.
(2019) Melleolides impact fungal translation via Elongation Factor 2. Org Biomol Chem 17, 4906-4916.
(2019) Production options for psilocybin - The making of the magic. Chem Eur J 25(4), 897-903. (Review)
(2019) Enzymatic route toward 6-methylated baeocystin and psilocybin. ChemBioChem 20, 2824-2829.
(2019) Melleolides from honey mushroom inhibit 5-lipoxygenase via Cys159. Cell Chem Biol 26(1), 60-70.e4.
(2019) Injury-Triggered Blueing Reactions of Psilocybe “Magic” Mushrooms. Angew Chem Intl Ed [Accepted]
(2018) Biocatalytic production of psilocybin and derivatives in tryptophan synthase-enhanced reactions. Chem Eur J 24(40), 10028-10031.
(2018) Iterative L-tryptophan methylation in Psilocybe evolved by sub-domain duplication. ChemBioChem [Accepted]
(2018) Multi-genome analysis identifies functional and phylogenetic diversity of basidiomycete adenylate-forming reductases. Fungal Genet Biol 112, 55-63.
(2018) Occurrence of European Tar Spot (Rhytisma acerinum) on Norway Maple causing severe infections in Minnesota. Plant Disease 102, 12.
(2018) Facile assembly and fluorescence-based screening method for heterologous expression of biosynthetic pathways in fungi. Metab Eng 48, 44-51.
(2018) Dissimilar pigment regulation in Serpula lacrymans and Paxillus involutus during interkingdom interactions. Microbiology 164(1), 65-77.
(2018) Analysis of basidiomycete pigments in situ by Raman spectroscopy. J Biophoton 11(6), e201700369.
(2017) Structure of ralsolamycin, the inter-kingdom morphogen of the crop plant pathogen Ralstonia solanacearum GMI1000. Org Lett 19, 4868-4871.
(2017) Biochemical and genetic basis of orsellinic acid biosynthesis and prenylation in a stereaceous basidiomycete. Fungal Genet Biol 98, 12-19.
(2017) A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Appl Environ Microbiol ,
(2017) A highly conserved basidiomycete peptide synthetase produces a trimeric hydroxamate siderophore. Appl Environ Microbiol [Accepted]
(2017) Induced chemical defense of a mushroom by a double-bond-shifting polyene synthase. Angew Chem Int Ed 56(21), 5937-5941.
(2017) Enzymatic synthesis of psilocybin Angew Chem Int Ed 56, 12352-12355.
(2017) Identification of N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product. J Nat Prod 80, 2835-2838.
(2017) Fungal variegatic acid and extracellular polysaccharides promote the site specific generation of reactive oxygen species J Ind Microbiol Biotechnol 44, 329-338.
(2016) Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus. Nat Chem Biol 12, 419-424.
(2016) A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis Beilstein J Org Chem 12, 2766-2770.
(2016) Active-Site Engineering Expands the Substrate Profile of the Basidiomycete L-Tryptophan Decarboxylase CsTDC. ChemBioChem 17, 132-136.
(2016) An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides. ChemBioChem 17, 1813-1817.
(2016) Globally distributed root endophyte Phialocephala subalpina links pathogenic and saprophytic lifestyles BMC Genomics 17, 1015.
(2016) Unexpected metabolic versatility in a combined fungal fomannoxin/vibralactone biosynthesis. J. Nat. Prod. 79, 1407-1414.
(2016) Ectomycorrhizal fungi decompose soil organic matter using oxidative mechanisms adapted from saprotrophic ancestors. New Phytol 209, 1705-1719.
(2016) Involutin is a Fe3+ reductant Secreted by the Ectomycorrhizal Fungus Paxillus involutus during Fenton-based Decomposition of Organic Matter. Appl Environ Microbiol 81, 8427-8433.
(2016) Bacteria induce pigment formation in the basidiomycete Serpula lacrymans. Environ Microbiol 18, 5218-5227.
(2016) A fivefold parallelized biosynthetic process secures chlorination of Armillaria mellea (honey mushroom) toxins. Appl Environ Microbiol 82, 1196-1204.
(2015) Three redundant synthetases secure redox-active pigment production in the basidiomycete Paxillus involutus. Chem Biol 22, 1325-1334.
(2015) Genetic engineering activates biosynthesis of aromatic fumaric acid amides in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 81, 1594-1600.
(2015) Activity of α-aminoadipate reductase depends on the N-terminally extending domain. Chembiochem 16, 1426-1430.
(2015) Insights on the Evolution of Mycoparasitism from the Genome of Clonostachys rosea. Genome Biol Evol 7, 465-480.
(2015) Fungal natural products-the mushroom perspective. Front Microbiol 6, 127.
(2014) Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships. Phytochemistry 105, 101-108.
(2014) Melleolides induce rapid cell death in human primary monocytes and cancer cells. Bioorg Med Chem 22, 3856-3861.
(2014) Biosynthesis of the Halogenated Mycotoxin Aspirochlorine in Koji Mold Involves a Cryptic Amino Acid Conversion. Angew Chem Int Ed Engl 53, 13409-13413.
(2014) Analysis of the Phlebiopsis gigantea Genome, Transcriptome and Secretome Provides Insight into Its Pioneer Colonization Strategies of Wood. PLOS Genet 10, e1004759.
(2014) Functional and phylogenetic divergence of fungal adenylate-forming reductases. Appl Environ Microbiol 80, 6175-6183.
(2014) Comments on the distribution and phylogeny of type I polyketide synthases and nonribosomal peptide synthetases in eukaryotes. Proc Natl Acad Sci U S A 111, E3946.
(2014) Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete J Nat Prod 77, 2658-2663.
(2013) The fusarin analogue NG-391 impairs transcription in K-562 leukemia cells Phytochemistry Letters 6, 189-192.
(2013) A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculans. Fungal Genet Biol 53, 50-58.
(2013) Homologous NRPS-like gene clusters mediate redundant small-molecule biosynthesis in Aspergillus flavus. Angew Chem Int Ed Engl 52, 1590-1594.
(2013) An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin. Chem Biol 20, 764-771.
(2013) Fungal peptide synthetases – an update on functions and specificity signatures Fungal Biology Reviews 27, 43-50.
(2013) Assembly of melleolide antibiotics involves a polyketide synthase with cross-coupling activity. Chem Biol 20, 1101-1106.
(2013) Ralfuranone thioether production by the plant pathogen Ralstonia solanacearum. Chembiochem 14, 2169-2178.
(2013) Bimodular peptide synthetase SidE produces fumarylalanine in the human pathogen Aspergillus fumigatus. Appl Environ Microbiol 79, 6670-6676.
(2012) Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proc Natl Acad Sci U S A 109, 5458-5463.
(2012) Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases. Fungal Genet Biol 49, 996-991003.
(2012) Sesquiterpene aryl ester natural products in North American Armillaria species Mycol Progress 11, 7-15.
(2012) Characterization of the Suillus grevillei quinone synthetase GreA supports a nonribosomal code for aromatic α-keto acids. Chembiochem 13, 1798-1804.
(2011) Secrets of the subterranean pathosystem of Armillaria. Mol Plant Pathol 12, 515-534.
(2011) In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects. Bioorg Med Chem Lett 21, 2003-2006.
(2011) The plant cell wall-decomposing machinery underlies the functional diversity of forest fungi. Science 333, 762-765.
(2011) Biosynthesis of a complex yersiniabactin-like natural product via the mic locus in phytopathogen Ralstonia solanacearum. Appl Environ Microbiol 77, 6117-6124.
(2011) Characterisation of the ArmA adenylation domain implies a more diverse secondary metabolism in the genus Armillaria. Fungal Biol 115, 775-781.
(2011) Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes. Chem Biol 18, 354-360.
(2009) The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearum. Chembiochem 10, 2730-2732.
(2008) Processing sites involved in intron splicing of Armillaria natural product genes. Mycol Res 112, 216-224.
(2008) The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones. Fungal Genet Biol 45, 302-309.
(2007) Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA. Fungal Genet Biol 44, 1134-1145.
(2007) Natural products of filamentous fungi: enzymes, genes, and their regulation. Nat Prod Rep 24, 393-416.
(2007) Fungal genetics, genomics, and secondary metabolites in pharmaceutical sciences. Planta Med 73, 103-115.
(2007) A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones. Chem Biol 14, 635-644.
(2006) Genomic mining for Aspergillus natural products. Chem Biol 13, 31-37.
(2005) Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase. J Biol Chem 280, 22508-22514.
(2005) Generation of novel landomycins M and O through targeted gene disruption. Chembiochem 6, 675-678.
(2004) The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl 43, 2962-2965.
(2004) Mechanistic implications of Escherichia coli galactokinase structure-based engineering. Chembiochem 5, 989-992.
(2004) Rational saccharide extension by using the natural product glycosyltransferase LanGT4. Chembiochem 5, 369-371.
(2004) Structure-based enzyme engineering and its impact on in vitro glycorandomization. Chembiochem 5, 16-25.
(2003) The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J Am Chem Soc 125, 4678-4679.
(2003) Creation of the first anomeric D/L-sugar kinase by means of directed evolution. Proc Natl Acad Sci U S A 100, 13184-13189.
(2003) Procaryotic and eucaryotic cells in biotech production In: Kayser O, Müller R. H. (eds.) Pharmaceutical Biotechnology, Drug Discovery and Clinical Applications pp. 9-33. Wiley-Blackwell.
(2003) Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators. FEMS Microbiol Lett 222, 149-153.
(2003) Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem 4, 109-111.
(2002) Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol 9, 287-295.
(2001) Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity. Chem Biol 8, 557-567.
(2001) Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics. Chem Biol 8, 569-581.
(2000) Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tü2717. Microbiology 146 ( Pt 1), 147-154.
(2000) The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster. Chem Biol 7, 821-831.
(2000) Function of glycosyltransferase genes involved in urdamycin A biosynthesis. Chem Biol 7, 133-142.