Hans Peter Saluz

Prof. Dr. Hans Peter Saluz

Cell and Molecular Biology · Head

Phone: +49 3641 532-1201 Fax: +49 3641 532-0805 Email: hanspeter.saluz@leibniz-hki.de

Main Research Areas
  • Flow of molecular information concerning host/pathogen interactions; virulence and host preference
- Pathogen models: chlamydia and aspergilli
- Host models: human material, chicken embryones, mouse     
- Methods: comparative genomics, dual RNA-Seq, EVIAT,in vivo ChIP-Seq, molecular imaging, single infection
  • Genomics of microbial  communities (metagenomics)
- Methods: 16S-amplicon analyses, complete DNA-metagenomics
  • Technological developments: UV-Laser ChIP-Seq, hyperspectral imaging
Curriculum vitae

Professional Career

Since 1995  Professor in cell and molecular biology at the Friedrich-Schiller-University Jena
1994 Habilitation in molecular biology (Dr. rer. nat. habil.) at the Friedrich-Schiller-University Jena
Since 1993 Supervisor (cell- and molecular biology) at the Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute – (HKI) Jena
1990-1993 Senior group and project leader at the IRBM (American-Italian Research Institute ) in Rome, Italy. Technological developments and studies in virus latency concerning Herpes simplex
1987-1990 Research associate at the Friedrich Miescher-Institute in Basel, Switzerland, studies in gene regulations; development of technologies for studying gene expressions in vivo
1984-1987 Postdoc at the Friedrich Miescher-Institut in Basel, Switzerland; studies in chicken  vitellogenin-II-gene regulation; development of methods for studying gene expressions in vivo
1984 PhD in philosophy (Dr. phil.) at the University Zurich, Switzerland
Dealing with "small nuclear RNAs" (strukture, function) at the University Zurich, Switzerland
1980 Diploma (Dipl. phil.): characterisation and function of sexpeptides and free amino acids in Drosophila macrospina at the University Zurich, Switzerland
1978-1980 Diploma programme  at the University Zurich, Switzerland (biochemistry, insect biochemistry, genetics, physical chemistry)
1979-1984 Training and research assistant (insect biochemistry) at the University Zurich, Switzerland
1975-1978 Bachelor programme at the University Zurich, Switzerland (chemistry, biology, physics, mathematics)

Awards · Appointments · Scientific Activities

Since 2007  Principal Investigator at the excellence graduate school Jena School for Microbial Communication (JSMC) 
Since 2006 Principal Investigator at the International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
Since 2005 Member of the scientific board of the Vietnam Red Cross Society
Since 2004 Principal Investigator at the International Max Planck Research School on The Exploration of Ecological Interactions with Molecular and Chemical Techniques (IMPRS)
Since 1997 Planning and contribution of startups
1997 Appointment to the management board of „BioRegio“ Jena (research political organisation, forschungspolitische Organisation, cross-strategic issues, company establishments, key areas of research, projects, technology transfer, etc.)
Since 1992 Consulting and evaluation activities for several national and international, scientific, industrial and state organisations and banks                        
Editorial work for several publishers                        
Member of several editorial boards
Publications

Hermenau R, Ishida K, Gama S, Hoffmann B, Pfeifer-Leeg M, Plass W, Mohr JF, Wichard T, Saluz HP, Hertweck C (2018) Gramibactin is a bacterial siderophore with a diazeniumdiolate ligand system. Nat Chem Biol 14(9), 841-843. Details PubMed

Bartels B, Kulkarni P, Böcker S, Saluz HP, Svatos A (2017) Mapping metabolites from rough terrain: laser ablation electrospray ionization on non-flat samples. RSC Adv 7, 9045-9050. Details

Hoffmann B*, Svensson C-M*, Straßburger M, Gebser B, Irmler IM, Kamradt T, Saluz HP, Figge MT, *authors contributed equally (2017) Automated quantification of early bone alterations and pathological bone turnover in experimental arthritis by in vivo PET/CT imaging. Sci Rep 7, 2217. Details PubMed Open Access PDF

Pohlers S, Martin R, Krüger T, Hellwig D, Hänel F, Kniemeyer O, Saluz HP, Van Dijck, Ernst JF, Brakhage A, Mühlschlegel FA, Kurzai O (2017) Lipid signaling via Pkh1/2 regulates fungal CO2 sensing through the kinase Sch9. mBio 8(1), e02211-16. Details PubMed

Steube A, Schenk T, Tretyakov A, Saluz HP (2017) High-intensity UV laser CHIP-seq for the study of protein-DNA interactions in living cells. Nat Commun 8(1), 1303. Details PubMed

Svensson C-M*, Hoffmann B*, Irmler I, Straßburger M, Figge MT**, Saluz HP**; *authors contributed equally; **corresponding authors, authors contributed equally (2017) Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data. Sci Rep 7, 44434. Details PubMed Open Access PDF Supplement

Beder T, Scheven MT, Praetzsch D, Westermann M, Saluz HP (2016) Purification of infectious and non-infectious chlamydial particles using iodixanol for density gradient preparation. J Microbiol Methods 128, 20-23. Details

Hänel F, Saluz HP (2016) Chlamydiacae: Polymorphic membrane proteins make the difference. Virulence 7(1), 3-4. (Review) Details

Hennersdorf P, Kleinertz S, Theisen S, Abdul-Aziz MA, Mrotzek G, Palm HW, Saluz HP (2016) Microbial diversity and parasitic load in tropical fish of different environmental conditions PLOS ONE 11(3), e0151594. Details

Hennersdorf P, Mrotzek G, Abdul-Aziz MA, Saluz HP (2016) Metagenomic analysis between free-living and cultured Epinephelus fuscoguttatus under different environmental conditions in Indonesian waters Mar Pollut Bull 110(2), 726-734. Details

Mohebbi S, Erfurth F, Hennersdorf P, Brakhage AA, Saluz HP (2016) Hyperspectral imaging using intracellular spies: quantitative real-time measurement of intracellular parameters in vivo during interaction of the pathogenic fungus Aspergillus fumigatus with human monocytes PLOS ONE 11(10), e0163505. Details

Oetama VS, Hennersdorf P, Abdul-Aziz MA, Mrotzek G, Haryanti H, Saluz HP (2016) Microbiome analysis and detection of pathogenic bacteria of Penaeus monodon from Jakarta Bay and Bali Mar Pollut Bull 110(2), 718-725. Details

Walther E, Xu Z, Richter M, Kirchmair J, Grienke U, Rollinger JM, Krumbholz A, Saluz HP, Pfister W, Sauerbrei A, Schmidtke M (2016) Dual acting neuraminidase inhibitors open new opportunities to disrupt the lethal synergism between Streptococcus pneumoniae and influenza virus Front Microbiol 7, 375. Details

Kästner J, Saluz HP, Hänel F (2015) Identification of in vivo-induced bacterial protein antigens during calf infection with Chlamydia psittaci Int J Med Microbiol 305(3), 310-321. Details

Krügel H, Klimina KM, Mrotzek G, Tretyakov A, Schöfl G, Saluz HP, Brantl S, Poluektova EU, Danilenko VN (2015) Expression of the toxin-antitoxin genes yefM, yoeB in human Lactobacillus rhamnosus isolates J Basic Microbiol 55(8), 982-991. Details

Muslihudeen AA, Schöfl G, Mrotzek G, Haryanti H, Sugama K, Saluz HP (2015) Population structure of the Indonesian giant tiger shrimp Penaeus monodon: a window into evolutionary similarities between paralogous mitochondrial DNA sequences and their genomes. Ecology and Evolution 5(17), 3570-3584. Details

Walther E, Richter M, Xu Z, Kramer C, von Grafenstein S, Kirchmair J, Grienke U, Rollinger JM, Liedl KR, Slevogt H, Sauerbrei A, Saluz HP, Pfister W, Schmidtke M (2015) Antipneumococcal activity of neuramidase inhibiting artocarpin Int J Med Microbiol 305, 289-297. Details

Böcker S, Heurich A, Franke C, Monajembashi S, Sachse K, Saluz HP, Hänel F (2014) Chlamydia psittaci inclusion membrane protein IncB associates with host protein Snapin. Int J Med Microbiol 304(5-6), 542-553. Details PubMed

Fatangare A, Gebhardt P, Saluz H, Svatoš A (2014) Comparing 2-[(18)F]fluoro-2-deoxy-D-glucose and [(68)Ga]gallium-citrate translocation in Arabidopsis thaliana. Nucl Med Biol 41(9), 737-743. Details PubMed

Irmler IM, Gebhardt P, Hoffmann B, Opfermann T, Figge MT, Saluz HP, Kamradt T (2014) 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis. Arthritis Res Ther 16(4), R155. Details PubMed Open Access

Knittler MR, Berndt A, Böcker S, Dutow P, Hänel F, Heuer D, Kägebein D, Klos A, Koch S, Liebler-Tenorio E, Ostermann C, Reinhold P, Saluz HP, Schöfl G, Sehnert P, Sachse K (2014) Chlamydia psittaci: New insights into genomic diversity, clinical pathology, host-pathogen interaction and anti-bacterial immunity. Int J Med Microbiol 304(7), 877-893. Details PubMed

Bleicher A, Schöfl G, Rodicio Mdel R, Saluz HP (2013) The plasmidome of a Salmonella enterica serovar Derby isolated from pork meat. Plasmid 69(3), 202-210. Details PubMed

Gebhardt P, Würbach L, Heidrich A, Heinrich L, Walther M, Opfermann T, Sørensen B, Saluz HP (2013) Dynamic behaviour of selected PET tracers in embryonated chicken eggs. Rev Esp Med Nucl Imagen Mol. 32(6), 371-377. Details PubMed

Heidrich A, Schmidt J, Zimmermann J, Saluz HP (2013) Automated segmentation and object classification of CT images: Application to in vivo molecular imaging of avian embryos. Int J Biomed Imaging 2013, 508474-508474. Details PubMed

Klimina KM, Kjasova DK, Poluektova EU, Krügel H, Leuschner Y, Saluz HP, Danilenko VN (2013) Identification and characterization of toxin-antitoxin systems in strains of Lactobacillus rhamnosus isolated from humans. Anaerobe 22, 82-89. Details PubMed

Rassmann A, Martin U, Saluz HP, Peter S, Munder T, Henke A (2013) Identification of gene expression profiles in HeLa cells and HepG2 cells infected with Coxsackievirus B3. J Virol Methods 187(1), 190-194. Details PubMed

Braukmann M, Sachse K, Jacobsen ID, Westermann M, Menge C, Saluz HP, Berndt A (2012) Distinct intensity of host-pathogen interactions in Chlamydia psittaci- and Chlamydia abortus-infected chicken embryos. Infect Immun 80(9), 2976-2988. Details PubMed

Kuhnert A, Schmidt U, Monajembashi S, Franke C, Schlott B, Grosse F, Greulich KO, Saluz HP, Hänel F (2012) Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins. J Cell Biochem 113(5), 1744-1753. Details PubMed

Ohlenschläger O, Kuhnert A, Schneider A, Haumann S, Bellstedt P, Keller H, Saluz HP, Hortschansky P, Hänel F, Grosse F, Görlach M, Pospiech H (2012) The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif. Nucleic Acids Res 40(17), 8309-8324. Details PubMed

Voigt A, Schöfl G, Saluz HP (2012) The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens. PLOS One 7(4), e35097-e35097. Details PubMed

Würbach L, Heidrich A, Opfermann T, Gebhardt P, Saluz HP (2012) Insights into bone metabolism of avian embryos in ovo via 3D and 4D 18F-fluoride positron emission tomography. Mol Imaging Biol 14(6), 688-698. Details PubMed

Borth N, Litsche K, Franke C, Sachse K, Saluz HP, Hänel F (2011) Functional interaction between type III-secreted protein IncA of Chlamydophila psittaci and human G3BP1. PLOS One 6(1), e16692-e16692. Details PubMed

Heidrich A, Würbach L, Opfermann T, Saluz HP (2011) Motion-artifact-free in vivo imaging utilizing narcotized avian embryos in ovo. Mol Imaging Biol 13(2), 208-214. Details PubMed

Kreutzer MF, Kage H, Gebhardt P, Wackler B, Saluz HP, Hoffmeister D, Nett M (2011) Biosynthesis of a complex yersiniabactin-like natural product via the mic locus in phytopathogen Ralstonia solanacearum. Appl Environ Microbiol 77, 6117-6124. Details PubMed

Schöfl G, Voigt A, Litsche K, Sachse K, Saluz HP (2011) Complete genome sequences of four mammalian isolates of Chlamydophila psittaci. J Bacteriol 193(16), 4258-4258. Details PubMed

Voigt A, Schöfl G, Heidrich A, Sachse K, Saluz HP (2011) Full-length de novo sequence of the Chlamydophila psittaci type strain, 6BC. J Bacteriol 193(10), 2662-2663. Details PubMed

Volling K, Thywissen A, Brakhage AA, Saluz HP (2011) Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. Cell Microbiol 13(8), 1130-1148. Details PubMed

Walther E, Schöfl G, Mrotzek G, Haryanti K, Sugama HP, Saluz (2011) Paralogous mitochondrial control region in the giant tiger shrimp, Penaeus monodon (F.) affects population genetics inference: A cautionary tale. Mol Phylogenet Evol 58(2), 404-408. Details PubMed

Walther M, Gebhardt P, Grosse-Gehling P, Würbach L, Irmler I, Preusche S, Khalid M, Opfermann T, Kamradt T, Steinbach J, Saluz HP (2011) Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT. Appl Radiat Isot 69(6), 852-857. Details PubMed

Krügel H, Licht A, Biedermann G, Petzold A, Lassak J, Hupfer Y, Schlott B, Hertweck C, Platzer M, Brantl S, Saluz HP (2010) Cervimycin C resistance in Bacillus subtilis is due to a promoter up-mutation and increased mRNA stability of the constitutive ABC-transporter gene bmrA. FEMS Microbiol Lett 313(2), 155-163. Details PubMed

Mrotzek G, Haryanti, Koesharyani I, Tretyakov AN, Sugama K, Saluz HP (2010) Fast short-fragment PCR for rapid and sensitive detection of shrimp viruses J Virol Methods 168(1-2), 262-266. Details

Erfurth F, Tretyakov A, Nyuyki B, Mrotzek G, Schmidt WD, Fassler D, Saluz HP (2008) Two-laser, large-field hyperspectral microarray scanner for the analysis of multicolor microarrays Anal Chem 80(20), 7706-7713. Details

Volling K, Brakhage AA, Saluz HP (2007) Apoptosis inhibition of alveolar macrophages upon interaction with conidia of Aspergillus fumigatus. FEMS Microbiol Lett 275(2), 250-254. Details PubMed