Sina Gerbach

Dr. Sina Gerbach

Administration Transfer Group Anti-infectives

Phone: +49 3641 532-1335 Fax: +49 3641 532-2335 Email: sina.gerbach@leibniz-hki.de

Curriculum vitae

Professional Career

since 2016 Scientific Coordinator, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany
2011 - 2016 Postdoc, Prof. P. Bastiaens, Max Planck Institute for Molecular Physiology, Dortmund, Germany, Activity of cMet during liver regeneration
2009 - 2011 Postdoc, Prof. L. Claesson-Welsh, Uppsala University, Sweden, NRP1 guides VEGFR2-mediated endothelial cell growth and tumor initiation.
2008 Postdoc, Prof. C. Thiede, University Hospital Dresden, Germany
2003 - 2007 PhD, Prof. C. Thiede, University Hospital Dresden, Germany, Receptor tyrosinkinase FLT3 in leukemic cells
2002 guest scientist, Prof. H. Sjöström, University of Copenhagen, Denmark
2003 Diploma in Biochemistry of Nutrition, University of Potsdam,G-protein-coupled receptor F2alpha
1997 - 2003 Studies in Science of Nutrition, University of Potsdam, Germany
Publications

Koch S, Helbing I, Böhmer SA, Hayashi M, Claesson-Welsh L, Söderberg O, Böhmer FD (2016) In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions. Methods Mol Biol 1447, 217-242. Details PubMed

Koch S, van Meeteren LA, Morin E, Testini C, Weström S, Björkelund H, Le Jan S, Adler J, Berger P, Claesson-Welsh L (2014) NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Dev Cell 28(6), 633-646. Details PubMed

Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, Koh GY, Dejana E, Belting HG, Affolter M, Thurston G, Holmgren L, Vestweber D, Claesson-Welsh L (2013) VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun 4, 1672. Details PubMed

Köthe S, Müller JP, Böhmer SA, Tschongov T, Fricke M, Koch S, Thiede C, Requardt RP, Rubio I, Böhmer FD (2013) Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells. J Cell Sci 126(Pt 20), 4746-4755. Details PubMed

Ortlepp C, Steudel C, Heiderich C, Koch S, Jacobi A, Ryser M, Brenner S, Bornhäuser M, Brors B, Hofmann WK, Ehninger G, Thiede C (2013) Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation. Exp Hematol 41(5), 444-461.e4. Details PubMed

Koch S (2012) Neuropilin signalling in angiogenesis. Biochem Soc Trans 40(1), 20-25. Details PubMed

Koch S, Claesson-Welsh L (2012) Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2(7), a006502. Details PubMed

Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L (2011) Signal transduction by vascular endothelial growth factor receptors. Biochem J 437(2), 169-183. Details PubMed

Tugues S, Koch S, Gualandi L, Li X, Claesson-Welsh L (2011) Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer. Mol Aspects Med 32(2), 88-8111. Details PubMed

Jacobi A, Thieme S, Lehmann R, Ugarte F, Malech HL, Koch S, Thiede C, Müller K, Bornhäuser M, Ryser M, Brenner S (2010) Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. Exp Hematol 38(3), 180-190. Details PubMed

Nilsson I, Bahram F, Li X, Gualandi L, Koch S, Jarvius M, Söderberg O, Anisimov A, Kholová I, Pytowski B, Baldwin M, Ylä-Herttuala S, Alitalo K, Kreuger J, Claesson-Welsh L (2010) VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J 29(8), 1377-1388. Details PubMed

Stölzel F, Steudel C, Oelschlägel U, Mohr B, Koch S, Ehninger G, Thiede C (2010) Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells. Ann Hematol 89(7), 653-662. Details PubMed

Schmidt-Arras D, Böhmer SA, Koch S, Müller JP, Blei L, Cornils H, Bauer R, Korasikha S, Thiede C, Böhmer FD (2009) Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality. Blood 113(15), 3568-3576. Details PubMed

Verstraete K, Koch S, Ertugrul S, Vandenberghe I, Aerts M, Vandriessche G, Thiede C, Savvides SN (2009) Efficient production of bioactive recombinant human Flt3 ligand in E. coli. Protein J 28(2), 57-65. Details PubMed

Koch S, Jacobi A, Ryser M, Ehninger G, Thiede C (2008) Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis. Cells Tissues Organs 188(1-2), 225-235. Details PubMed

Thiede C, Koch S, Creutzig E, Steudel C, Illmer T, Schaich M, Ehninger G (2006) Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 107(10), 4011-4020. Details PubMed

Koch S, Anthonsen D, Skovbjerg H, Sjöström H (2003) On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. Adv Exp Med Biol 524, 181-187. Details PubMed

Neuschäfer-Rube F, Engemaier E, Koch S, Böer U, Püschel GP (2003) Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J 371(Pt 2), 443-449. Details PubMed