|since 2016||Scientific Coordinator, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany|
|2011 - 2016||Postdoc, Prof. P. Bastiaens, Max Planck Institute for Molecular Physiology, Dortmund, Germany, Activity of cMet during liver regeneration|
|2009 - 2011||Postdoc, Prof. L. Claesson-Welsh, Uppsala University, Sweden, NRP1 guides VEGFR2-mediated endothelial cell growth and tumor initiation.|
|2008||Postdoc, Prof. C. Thiede, University Hospital Dresden, Germany|
|2003 - 2007||PhD, Prof. C. Thiede, University Hospital Dresden, Germany, Receptor tyrosinkinase FLT3 in leukemic cells|
|2002||guest scientist, Prof. H. Sjöström, University of Copenhagen, Denmark|
|2003||Diploma in Biochemistry of Nutrition, University of Potsdam,G-protein-coupled receptor F2alpha|
|1997 - 2003||Studies in Science of Nutrition, University of Potsdam, Germany|
(2016) In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions. Methods Mol Biol 1447, 217-242.
(2014) NRP1 presented in trans to the endothelium arrests VEGFR2 endocytosis, preventing angiogenic signaling and tumor initiation. Dev Cell 28(6), 633-646.
(2013) VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun 4, 1672.
(2013) Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals through K-Ras at the plasma membrane of acute myeloid leukemia cells. J Cell Sci 126(Pt 20), 4746-4755.
(2013) Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation. Exp Hematol 41(5), 444-461.e4.
(2012) Neuropilin signalling in angiogenesis. Biochem Soc Trans 40(1), 20-25.
(2012) Signal transduction by vascular endothelial growth factor receptors. Cold Spring Harb Perspect Med 2(7), a006502.
(2011) Signal transduction by vascular endothelial growth factor receptors. Biochem J 437(2), 169-183.
(2011) Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer. Mol Aspects Med 32(2), 88-8111.
(2010) Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts. Exp Hematol 38(3), 180-190.
(2010) VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts. EMBO J 29(8), 1377-1388.
(2010) Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells. Ann Hematol 89(7), 653-662.
(2009) Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality. Blood 113(15), 3568-3576.
(2009) Efficient production of bioactive recombinant human Flt3 ligand in E. coli. Protein J 28(2), 57-65.
(2008) Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis. Cells Tissues Organs 188(1-2), 225-235.
(2006) Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML). Blood 107(10), 4011-4020.
(2003) On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease. Adv Exp Med Biol 524, 181-187.
(2003) Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J 371(Pt 2), 443-449.