
Dr. habil. Markus Nett
Secondary Metabolism of Predatory Bacteria · Head
Phone: +49 3641 532-1297 Fax: +49 3641 532-2927 Email: markus.nett@leibniz-hki.de
- Identification and characterisation of antimicrobial natural products
- Genome mining
- Biosynthesis of antibiotics and compounds-engineering
Professional Career
2014 | Visiting professor in pharmacognosy, University Vienna |
2014 | Habilitation in pharmacy, Friedrich-Schiller-University Jena |
Since 2009 | Head of a junior research group, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI) Jena |
2007-2008 | Research assistant, Scripps Institution of Oceanography, Center for Marine Biotechnology and Biomedicine, San Diego, USA, funded through a DAAD-postdoc-fellowship |
2007 | PhD in pharmacy, Rheinische Friedrich-Wilhelms-University Bonn |
2002 | License to practice as a chemist |
1997-2001 | Studies in pharmacy, Rheinische Friedrich-Wilhelms-University Bonn |
(2019) A genomics perspective on natural product biosynthesis in plant pathogenic bacteria Nat Prod Rep 36(2), 307-325. (Review) Details PubMed
(2017) Structure of ralsolamycin, the inter-kingdom morphogen of the crop plant pathogen Ralstonia solanacearum GMI1000. Org Lett 19, 4868-4871. Details
(2017) Induced chemical defense of a mushroom by a double-bond-shifting polyene synthase. Angew Chem Int Ed 56(21), 5937-5941. Details PubMed
(2017) Discovery of an Extended Austinoid Biosynthetic Pathway in Aspergillus calidoustus. ACS Chem Biol 12(5), 1227-1234. Details PubMed Supplement
(2016) A non-canonical peptide synthetase adenylates 3-methyl-2-oxovaleric acid for auriculamide biosynthesis Beilstein J Org Chem 12, 2766-2770. Details
(2016) An Iterative O-Methyltransferase Catalyzes 1,11-Dimethylation of Aspergillus fumigatus Fumaric Acid Amides. ChemBioChem 17, 1813-1817. Details PubMed
(2016) Antibiotics from predatory bacteria. Beilstein J Org Chem 12, 594-607. (Review) Details
(2016) Siderophores as molecular tools in medical and environmental applications. Org Biomol Chem 14(35), 8212-8227. Details PubMed
(2016) Variochelins, lipopeptide siderophores from Variovorax boronicumulans discovered by genome mining. J Nat Prod 79(4), 865-872. Details PubMed
(2016) The 5-lipoxygenase inhibitor RF-22c potently suppresses leukotriene biosynthesis in cellulo and blocks bronchoconstriction and inflammation in vivo. Biochem Pharmacol 112, 60-71. Details PubMed
(2016) A fast and efficient method for the preparation of the 5-lipoxygenase inhibitor myxochelin A. Tetrahedron Lett 57, 1359-1360. Details
(2016) Unexpected metabolic versatility in a combined fungal fomannoxin/vibralactone biosynthesis. J. Nat. Prod. 79, 1407-1414. Details
(2016) Unraveling the predator-prey relationship of Cupriavidus necator and Bacillus subtilis. Microbiol Res 192, 231-238. Details
(2016) Zincophorin – biosynthesis in Streptomyces griseus and antibiotic properties GMS Infect Dis 4, Doc08. Details Open Access
(2015) Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus. J Antibiot (Tokyo) 68, 463-468. Details PubMed
(2015) Biosynthetic origin of the antibiotic pseudopyronines A and B in Pseudomonas putida BW11M1. ChemBioChem 16, 2491-2497. Details
(2015) Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase. Org Biomol Chem 13, 11414-11417. Details
(2015) Harnessing enzymatic promiscuity in myxochelin biosynthesis for the production of 5-lipoxygenase inhibitors. ChemBioChem 16, 2445-2450. Details
(2015) Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11, 625-631. Details
(2015) Structure and absolute configuration of auriculamide, a natural product from the predatory bacterium Herpetosiphon aurantiacus. Eur J Org Chem 14, 3057-3062. Details
(2015) Myxochelins target human 5-lipoxygenase. J Nat Prod 78(2), 335-338. Details PubMed
(2015) Quantitative analysis of Lysobacter predation. Appl Environ Microbiol 81(20), 7098-7105. Details
(2014) Genome mining – concept and strategies for natural product discovery. In: Kinghorn DA, Falk H, Kobayashi J (eds.) Prog Chem Org Nat Prod 99, pp. 199-245. Springer, Switzerland. Details
(2014) Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA. J Biol Chem 289(12), 8151-8169. Details PubMed
(2014) New myxothiazols from the predatory bacterium Myxococcus fulvus. J Antibiot 67(7), 519-525. Details PubMed
(2014) Structure and Biosynthetic Assembly of Gulmirecins, Macrolide Antibiotics from the Predatory Bacterium Pyxidicoccus fallax. Chem Eur J 20, 15933-15940. Details PubMed
(2014) Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete J Nat Prod 77, 2658-2663. Details PubMed
(2013) A gene cluster responsible for biosynthesis of phomenoic acid in the plant pathogenic fungus, Leptosphaeria maculans. Fungal Genet Biol 53, 50-58. Details PubMed
(2013) Micromonospora schwarzwaldensis sp. nov., a producer of telomycin, isolated from soil. Int J Syst Evol Microbiol 63(Pt 10), 3812-3817. Details PubMed
(2013) An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin. Chem Biol 20, 764-771. Details PubMed
(2013) Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem 14(8), 955-962. Details PubMed
(2013) Ralfuranone thioether production by the plant pathogen Ralstonia solanacearum. Chembiochem 14, 2169-2178. Details PubMed
(2012) 4-Hydroxyphenylglycine biosynthesis in Herpetosiphon aurantiacus: a case of gene duplication and catalytic divergence. Arch Microbiol 194(6), 557-566. Details PubMed
(2012) Structure and biosynthetic assembly of cupriachelin, a photoreactive siderophore from the bioplastic producer Cupriavidus necator H16. J Am Chem Soc 134(11), 5415-5422. Details PubMed
(2012) Genomics-driven discovery of taiwachelin, a lipopeptide siderophore from Cupriavidus taiwanensis. Org Biomol Chem 10(47), 9338-9343. Details PubMed
(2012) A microfluidics-based approach to drug discovery. Biomed Tech (Berl) 57(SI-1 Track-B), 270. Details
(2011) In vitro cytotoxicity of melleolide antibiotics: structural and mechanistic aspects. Bioorg Med Chem Lett 21, 2003-2006. Details PubMed
(2011) Complete genome sequence of the filamentous gliding predatory bacterium Herpetosiphon aurantiacus type strain (114-95(T)). Stand Genomic Sci 5(3), 356-370. Details PubMed
(2011) Biosynthesis of a complex yersiniabactin-like natural product via the mic locus in phytopathogen Ralstonia solanacearum. Appl Environ Microbiol 77, 6117-6124. Details PubMed
(2011) Farinamycin, a quinazoline from Streptomyces griseus. J Nat Prod 74(10), 2265-2268. Details PubMed
(2011) Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol 77(11), 3617-3625. Details PubMed
(2011) Ralfuranone biosynthesis in Ralstonia solanacearum suggests functional divergence in the quinone synthetase family of enzymes. Chem Biol 18, 354-360. Details PubMed
(2010) Pitucamycin: structural merger of a phenoxazinone with an epoxyquinone antibiotic. J Nat Prod 73(9), 1461-1464. Details PubMed
(2009) Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. J Med Chem 52(19), 6163-6167. Details PubMed
(2009) Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep 26(11), 1362-1384. (Review) Details PubMed
(2009) Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica Pure Appl Chem 81(6), 1075-1084. (Review) Details
(2009) Genomic islands link secondary metabolism to functional adaptation in marine Actinobacteria. ISME J 3(10), 1193-1203. Details PubMed
(2009) The global virulence regulators VsrAD and PhcA control secondary metabolism in the plant pathogen Ralstonia solanacearum. Chembiochem 10, 2730-2732. Details PubMed
(2008) Engineered biosynthesis of antiprotealide and other unnatural salinosporamide proteasome inhibitors. J Am Chem Soc 130(25), 7822-7823. Details PubMed
(2008) Unraveling the biosynthesis of the sporolide cyclohexenone building block. J Am Chem Soc 130(8), 2406-2407. Details PubMed
(2007) The chemistry of gliding bacteria. Nat Prod Rep 24(6), 1245-1261. (Review) Details PubMed
(2006) Siphonazole, an unusual metabolite from Herpetosiphon sp. Angew Chem Int Ed Engl 45(23), 3863-3867. Details PubMed
(2003) New cytotoxic cembrane based diterpenes from the soft corals Sarcophyton cherbonnieri and Nephthea sp. Org Biomol Chem 1(6), 944-949. Details PubMed