Hydractinia and Their Symbionts

Microbes associated with marine invertebrates are well-known to harbor an enormous biosynthetic potential. We combine new bioassays, genome sequencing and mining strategies to identify the encoded secondary metabolites with unique chemical scaffolds and potential pharmaceutical application.

shell overgrown with H. echiniata — shell overgrown with *H. echiniata*

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Marine Bacteria

Publications

Ghodsi Z, Kalbassi MR, Farzaneh P, Mobarez AM, Beemelmanns C, Amiri Moghaddam J (2020) Immunomodulatory function of antimicrobial peptide Ec-Hepcidin1 modulates the induction of inflammatory gene expression in primary cells of caspian trout (Salmo trutta caspius Kessler, 1877). Fish Shellfish Immunol 104, 55-61. Details PubMed Open Access PDF

Maniei F, Moghaddam JA, Crüsemann M, Beemelmanns C, König GM, Wägele H (2020) From Persian Gulf to Indonesia: Interrelated phylogeographic distance and chemistry within the genus Peronia (Onchidiidae, Gastropoda, Mollusca). Sci Rep 10(1), 13048. Details PubMed Open Access PDF

Rajabi H, Zolgharnein H, Taghi Ronagh M, Moghaddam JA, Crüsemann M (2020) Conus coronatus and Conus frigidus venom: A new source of conopeptides with analgesic activity. Avicenna J Med Biotechnol 12(3), 179-185. Details PubMed Open Access

Rak Lee S, Kang H, Yoo MJ, Yu JS, Lee S, Yi SA, Beemelmanns C, Lee J, Kim KH (2020) Anti-adipogenic pregnane steroid from a hydractinia-associated fungus, Cladosporium sphaerospermum sp. SW67. Nat Prod Sci 26(3), 230-235. Details Open Access Code

Roman D, Raguž L, Keiff F, Meyer F, Barthels F, Schirmeister T, Kloss F, Beemelmanns C (2020) Modular solid-phase synthesis of antiprotozoal barnesin derivatives. Org Lett 22(10), 3744-3748. Details PubMed

Lee SR, Lee D, Eom HJ, Rischer M, Ko YJ, Kang KS, Kim CS, Beemelmanns C, Kim KH (2019) Hybrid polyketides from a Hydractinia-associated Cladosporium sphaerospermum SW67 and their putative biosynthetic origin. Mar Drugs 17(11), 606. Details PubMed Open Access PDF

Rischer M, Lee SR, Eom HJ, Park HB, Vollmers J, Kaster AK, Shin JH, Oh DC, Kim KH, Beemelmanns C (2019) Spirocyclic cladosporicin A and cladosporiumins I and J from a Hydractinia-associated Cladosporium sphaerospermum SW67. Org Chem Front 6, 1084-1093. Details

Rischer M, Raguz L, Guo H, Keiff F, Diekert G, Goris T, Beemelmanns C (2018) Biosynthesis, synthesis and activities of barnesin A, a NRPS-PKS hybrid produced by an anaerobic Epsilonproteobacterium. ACS Chem Biol 13(8), 1990-1995. Details PubMed

Wichard T, Beemelmanns C (2018) Role of chemical mediators in aquatic interactionas across the prokaryote eukaryote boundary. J Chem Ecol 44(11), 1008-1021. (Review) Details PubMed Open Access PDF

Guo H, Rischer M, Sperfeld M, Weigel C, Menzel KD, Clardy J, Beemelmanns C (2017) Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata. Bioorg Med Chem 25(22), 6088-6097. Details PubMed Code

Rischer M, Klassen J, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C (2016) Draft Genome Sequence of Shewanella sp. P1-14-1, a Bacterial Inducer of Settlement and Morphogenesis in Larvae of the Marine Hydroid Hydractinia Echinata Genome Announc 4(1), e00003-16. Details PubMed

Klassen JL, Rischer M, Wolf T, Guo H, Shelest E, Clardy J, Beemelmanns C (2015) Genome Sequences of Three Pseudoalteromonas Strains P1-8, P1-11 and P1-30 Isolated from the Marine Hydroid Hydractinia echinata Genome Announc. 3(6), e01380-15. Details PubMed

Klassen JL, Wolf T, Rischer M, Guo H, Shelest E, Clardy J, Beemelmanns C (2015) Draft Genome Sequences of Six Pseudoalteromonas sp. Strains P1-7a, P1-9, P1-13-1a, P1-16-1b, P1-25 and P1-26, which Induce Larval Settlement and Metamorphosis in Hydractinia echinata Genome Announc. 3(6), e01477-15. Details PubMed

Staff