SBI members publishing in prestigious Journals

Happy to announce that our SBI scientific co-worker Dr. Wolfgang Schmidt-Heck is the co-author of the Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects’ a published paper in the Nature Communications Journal. The paper main focus is “The regulation disorder of extracellular signal-regulated kinases ERK1/2 is associated with various diseases. The inhibition of ERK1/2 leads to severe cardiac side effects, which precludes therapeutic application. ERKT188 autophosphorylation has been found to cause pathological cardiac hypertrophy. It could be shown that interference with ERK dimerization, a prerequisite for ERKT188 phosphorylation, minimizes cardiac hypertrophy without inducing cardiac side effects, thus allowing therapeutic application in ERK1/2-related diseases such as heart failure, cancer and genetic syndromes."  

Also happy to announce that another of our SBI scientific co-workers Dr. Sascha Schäuble is the co-author of Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C a published paper in Communications Biology Journal. The main contribution of Sascha was : " The study of PI3K/Akt signaling in contracting skeletal muscle cells by quantitative phosphoproteomics. A text mining pipeline was employed to reveal PI3K/Akt/mTOR network-associated proteins comprising the basophilic motifs. ‘Kinase activity’ associated events showed that Akt and PI3K are most prominent for proteins with the classical motif."

Congratulations to our researchers.