A new publication from the group in mSystems

| by Ana Depetris Chauvin

We are delighted that our research work entitled “Gut ecological networks reveals associations between bacteria, exercise, and clinical profile in non-alcoholic fatty liver disease patients” has been published in the journal mSystems.

Non-alcoholic fatty liver disease (NAFLD) is the most common disease afflicting the liver and currently affects >32% of the world population. No efficient medication is available to reverse NAFLD fat buildup in the liver, and patients are often advised to change their lifestyle, such as a diet change and following an exercise protocol.

In a fruitful collaboration with Prof. Ursula Schwab from the University of Eastern Finland (UEF), we have studied the role of the gut microbiome as a mediator of the beneficial effect of exercise.

Our study demonstrates that a 12-week high-intensity interval training alters how the gut microbiome species interact with each other, and these changes in the microbiome structure are associated with improvements in lipid content in the liver.

The project was led by Prof. Gianni Panagiotou, Prof. Ursula Schwab, and first authors Susanne Csader (UEF), Xiuqiang Chen (MBD-HKI), and Howell Leung (MBD-HKI). We are very grateful to our collaborators and funding sources from the German agencies DFG and Horizon EU research program, who may make this work possible.

Original Publication

Csader S*, Chen X*, Leung H*, Männistö V, Pentikäinen H, Tauriainen MM, Savonen K, El-Nezami H, Schwab U#, Panagiotou G# (2023) Gut ecological networks reveal associations between bacteria, exercise and clinical profile in non-alcoholic fatty liver disease patients. mSystems