New publication from the group in NPJ Biofilms and Microbiomes
| by Ana Depetris Chauvin
We are very pleased that our research work entitled “Impaired flux of bile acids from the liver to the gut reveals microbiome-immune interactions associated with liver damage” has been published in the journal NPJ Biofilms and Microbiomes.
Studies have shown that disruption of the gut ecosystem contributes to the development of liver disease, but how the gut-hepatic immune system is functionally connected when bile flow is blocked remains unclear.
In a mice model of bile duct obstruction, we have identified gut bacteria species and biosynthetic pathways reduced in the pathological condition and found correlations with cytokines and liver damage markers. Our findings advance the knowledge of the gut microbiome-bile acids-liver triangle, and we hope it may serve to develop potential therapeutic strategies to fight liver diseases.
The project was led by Prof. Gianni Panagiotou and first author Howell Leung in collaboration with MBD member Yueqiong Ni and external collaborators from Friedrich Schiller University Jena and the Jena University Hospital. We are very grateful to our collaborators and funding sources from the German agencies DFG and Horizon EU research program who may this work possible.
Original Publication
Leung H, Xiong L, Ni Y, Busch A, Bauer M, Press AT, Panagiotou G (2023) Impaired flux of bile acids from the liver to the gut reveals microbiome-immune interactions associated with liver damage NPJ Biofilms and Microbiomes