Prof. Dr. Peter F. Zipfel

Infection Biology · Head International Leibniz Research School · Speaker +49 3641 532-1301 peter.zipfel@leibniz-hki.de

Curriculum vitae

Main Research Areas

Immune escape of human pathogenic micro-organisms
Infection-associated function of the complement system
Genetic susceptibility for infections

Professional Career

Since 2000	Professor for infection biology, Friedrich-Schiller-University Jena (FSU Jena)
Since 2000	Head of the department infection biology, Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena
1999	Nontenured professor, University Hamburg
1993	Habilitation in immunology and molecular biology, University Hamburg
1989-2000	Group head at the Bernhard-Nocht-Institute for tropical medicine Hamburg
1989	Visiting associate, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA
1985-1988	Postdoc, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA, funded by the German Academic Exchange Service (DAAD)
1984	PhD as Dr. rer. nat., University Bremen
1980-1985	Research assistant, University Bremen
1980	Diploma in biology, University Bremen

Awards · Appointments · Scientific Activities

Since 2009	Member at the editorial board of molecular immunology, frontiers in innate immunity
2009	Excellence award from the Deutsche Gesellschaft für Hygiene und Mikrobiologie
Since 2008	Representative of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2008	EFIS lecture award of the European Federation of Immunological Societies
Since 2007	Principal investigator of the excellence graduate school Jena School for Microbial Communication (JSMC)
2007	Heinz Spitzbart award of the European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG)
Since 2006	Principal investigator of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2007-2011	President of the European Complement Network
2005 – 2012	Board member of the European Complement Network
2004	Thuringian research award
Since 2002	Deputy Director of the Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena
Since 2000	Project leader for infection biology, L2
1999-2001	Member at the editorial board of experimental and clinical immunology, thrombosis and haemostasis, section editor molecular immunology Member of the European Working Party on the Genetics of Complement mediated Kidney Diseases, Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM), Deutsche Gesellschaft für Immunologie, Gesellschaft für Genetik, Gesellschaft für Nephrologie

Publications

Brakhage AA, Kniemeyer O, Zipfel PF (2024) Human and animal relationships. In: Brakhage AA, Kniemeyer O, Zipfel PF (eds.) The Mycota - Human and animal relationships. 3. 6, pp. vii-viii. Springer, Cham. ISBN: 978-3-031-64853. (Review)

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Perie L^*, Stippa S^*, Saffer C^*, Hartmann A, Mörglin M, Zipfel SLH, Figge MT, Wiech T, Skerka C, Zipfel PF^# (2024) Unique target binding by the C-terminal Region of FHR1 provides a new perception of aHUS Pathology. Front Hematol 3, 10.3389/frhem.2024.1469176.

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Tschongov T, Konwar S, Busch A, Sievert C, Hartmann A, Noris M, Gastoldi S, Aiello S, Schaaf A, Panse J, Zipfel PF, Dabrowska-Schlepp P, Häffner K (2024) Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity. Front Immunol 15, 1383123.

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Battista M, Hoffmann B, Bachelot Y, Zimmermann L, Teuber L, Jost A, Linde S, Westermann M, Müller MM, Slevogt H, Hammerschmidt S, Figge MT, Vilhena C^*^#, Zipfel PF^*^# (2023) The role of pneumococcal extracellular vesicles on the pathophysiology of the kidney disease hemolytic uremic syndrome. mSphere 8(4), e0014223.

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Busch C, Rau S, Sekulic A, Perie L, Huber C, Gehrke M, Joussen AM, Zipfel PF, Wildner G, Skerka C, Strauß O (2023) Increased plasma level of terminal complement complex in AMD patients: potential functional consequences for RPE cells. Front Immunol 14, 1200725.

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Daud M, Dasari P, Adelfinger M, Langenhorst D, Lother J, Slavkovic-Lukic D, Berges C, Kruhm M, Galler A, Schleussner C, Luther CH, Alberter K, Althammer A, Shaikh H, Pallmann N, Bodem J, El-Mowafy M, Beilhack A, Dittrich M, Topp MS, Zipfel PF, Beyersdorf N (2023) Enolase 1 of Candida albicans binds human CD4+ T cells and modulates naïve and memory responses. Eur J Immunol 53(11), e2250284.

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Langenhorst D, Fürst AL, Alberter K, Vilhena C, Dasari P, Daud M, Heilig L, Luther CH, Dittrich M, Reiher N, Wich M, Elmowafy M, Jacobsen ID, Jungnickel B, Zipfel PF^*, Beyersdorf N^*^# (2023) Soluble enolase 1 of Candida albicans and Aspergillus fumigatus stimulates human and mouse B cells and monocytes. J Immunol 211(5), 804-815.

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Lin L, Wang M, Zeng J, Mao Y, Qin R, Deng J, Ouyang X, Hou X, Sun C, Wang Y, Cai Y, Li M, Tian C, Zhou X, Zhang M, Fan H, Mei H, Sarapultsev A, Wang H, Zhang G, Zipfel PF, Hu Y, Hu D, Luo S (2023) Sequence variation of Candida albicans Sap2 enhances fungal pathogenicity via complement evasion and macrophage M2-like phenotype induction. Adv Sci (Weinh) 10(20), e2206713.

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Noriega M, Husain-Syed F, Wulf S, Csala B, Krebs CF, Jabs W, Zipfel PF, Gröne HJ, Wiech T (2023) Kidney biopsy findings in patients with SARS-CoV-2 infection or after COVID-19 vaccination. Clin J Am Soc Nephrol 18(5), 613-625.

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Seifert L, Zahner G, Meyer-Schwesinger C, Hickstein N, Dehde S, Wulf S, Köllner SMS, Lucas R, Kylies D, Froembling S, Zielinski S, Kretz O, Borodovsky A, Biniaminov S, Wang Y, Cheng H, Koch-Nolte F, Zipfel PF, Hopfer H, Puelles VG, Panzer U, Huber TB, Wiech T, Tomas NM (2023) The classical pathway triggers pathogenic complement activation in membranous nephropathy. Nat Commun 14(1), 473.

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