Prof. Dr. Peter F. Zipfel

Infection Biology · Head International Leibniz Research School · Speaker +49 3641 532-1301 peter.zipfel@leibniz-hki.de

Curriculum vitae

Main Research Areas

Immune escape of human pathogenic micro-organisms
Infection-associated function of the complement system
Genetic susceptibility for infections

Professional Career

Since 2000	Professor for infection biology, Friedrich-Schiller-University Jena (FSU Jena)
Since 2000	Head of the department infection biology, Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena
1999	Nontenured professor, University Hamburg
1993	Habilitation in immunology and molecular biology, University Hamburg
1989-2000	Group head at the Bernhard-Nocht-Institute for tropical medicine Hamburg
1989	Visiting associate, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA
1985-1988	Postdoc, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA, funded by the German Academic Exchange Service (DAAD)
1984	PhD as Dr. rer. nat., University Bremen
1980-1985	Research assistant, University Bremen
1980	Diploma in biology, University Bremen

Awards · Appointments · Scientific Activities

Since 2009	Member at the editorial board of molecular immunology, frontiers in innate immunity
2009	Excellence award from the Deutsche Gesellschaft für Hygiene und Mikrobiologie
Since 2008	Representative of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2008	EFIS lecture award of the European Federation of Immunological Societies
Since 2007	Principal investigator of the excellence graduate school Jena School for Microbial Communication (JSMC)
2007	Heinz Spitzbart award of the European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG)
Since 2006	Principal investigator of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2007-2011	President of the European Complement Network
2005 – 2012	Board member of the European Complement Network
2004	Thuringian research award
Since 2002	Deputy Director of the Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena
Since 2000	Project leader for infection biology, L2
1999-2001	Member at the editorial board of experimental and clinical immunology, thrombosis and haemostasis, section editor molecular immunology Member of the European Working Party on the Genetics of Complement mediated Kidney Diseases, Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM), Deutsche Gesellschaft für Immunologie, Gesellschaft für Genetik, Gesellschaft für Nephrologie

Publications

Zipfel PF, Wiech T, Rudnick R, Afonso S, Person F, Skerka C (2019) Complement inhibitors in clinical trials for glomerular diseases. Front Immunol 10, 2166. (Review)

Details

Dasari P, Shopova IA, Stroe M, Wartenberg D, Dahse HM, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF (2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635.

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Dennhardt S, Pirschel W, Wissuwa B, Daniel C, Gunzer F, Lindig S, Medyukhina A, Kiehntopf M, Rudolph WW, Zipfel PF, Gunzer M, Figge MT, Amman K, Coldewey S (2018) Modeling hemolytic-uremic syndrome: In-depth characterization of distinct murine models reflecting different features of human disease. Front Immunol 9, 1459.

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Hummert S, Glock C, Lang SN, Hummert C, Skerka C, Zipfel PF, Germerodt S, Schuster S (2018) Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism. J R Soc Interface 15(142), 20170963.

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Irmscher S, Döring N, Halder LD, Jo EAH, Kopka I, Dunker C, Jacobsen ID, Luo S, Slevogt H, Lorkowski S, Beyersdorf N, Zipfel PF, Skerka C (2018) Kallikrein cleaves C3 and activates complement. J Innate Immun 10(2), 94-105.

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Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF (2018) The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol 93, 266-277.

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Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Cseresnyés Z, Coldewey SM, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF (2018) Streptococcus pneumoniae from patients with hemolytic uremic syndrome binds human plasminogen via the surface protein PspC and uses plasmin to damage human endothelial cells. J Infect Dis 217(3), 358-370.

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Michelfelder S, Fischer F, Wäldin A, Hörle K, Pohl M, Parsons J, Reski R, Decker EL, Zipfel PF, Skerka C, Häffner K (2018) The MFHR1 fusion protein is a novel synthetic multitarget complement inhibitor with therapeutic potential. J Am Soc Nephrol 29(4), 1141-1153.

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Pujol-Lereis LM, Liebisch G, Schick T, Lin Y, Grassmann F, Uchida K, Zipfel PF, Fauser S, Skerka C, Weber BHF (2018) Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration. PLOS One 13(8), e0200739.

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Reiss T, Rosa TFA, Blaesius K, Bobbert RP, Zipfel PF, Skerka C, Pradel G (2018) FHR-1 binding impairs factor H-mediated complement evasion by the malaria parasite Plasmodium falciparum. J Immunol 201(12), 3497-3502.

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