Prof. Dr. Peter F. Zipfel

Infection Biology · Head International Leibniz Research School · Speaker +49 3641 532-1301 peter.zipfel@leibniz-hki.de

Curriculum vitae

Main Research Areas

Immune escape of human pathogenic micro-organisms
Infection-associated function of the complement system
Genetic susceptibility for infections

Professional Career

Since 2000	Professor for infection biology, Friedrich-Schiller-University Jena (FSU Jena)
Since 2000	Head of the department infection biology, Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena
1999	Nontenured professor, University Hamburg
1993	Habilitation in immunology and molecular biology, University Hamburg
1989-2000	Group head at the Bernhard-Nocht-Institute for tropical medicine Hamburg
1989	Visiting associate, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA
1985-1988	Postdoc, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, Maryland, USA, funded by the German Academic Exchange Service (DAAD)
1984	PhD as Dr. rer. nat., University Bremen
1980-1985	Research assistant, University Bremen
1980	Diploma in biology, University Bremen

Awards · Appointments · Scientific Activities

Since 2009	Member at the editorial board of molecular immunology, frontiers in innate immunity
2009	Excellence award from the Deutsche Gesellschaft für Hygiene und Mikrobiologie
Since 2008	Representative of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2008	EFIS lecture award of the European Federation of Immunological Societies
Since 2007	Principal investigator of the excellence graduate school Jena School for Microbial Communication (JSMC)
2007	Heinz Spitzbart award of the European Society for Infectious Diseases in Obstetrics and Gynaecology (ESIDOG)
Since 2006	Principal investigator of the graduate school International Leibniz Research School for Microbial and Biomolecular Interactions (ILRS)
2007-2011	President of the European Complement Network
2005 – 2012	Board member of the European Complement Network
2004	Thuringian research award
Since 2002	Deputy Director of the Leibniz-Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute Jena
Since 2000	Project leader for infection biology, L2
1999-2001	Member at the editorial board of experimental and clinical immunology, thrombosis and haemostasis, section editor molecular immunology Member of the European Working Party on the Genetics of Complement mediated Kidney Diseases, Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM), Deutsche Gesellschaft für Immunologie, Gesellschaft für Genetik, Gesellschaft für Nephrologie

Publications

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C (2017) Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator. J Neuroinflammation 14(1), 4.

Details

Mühlenkamp MC, Hallström T, Autenrieth IB, Bohn E, Linke D, Rinker J, Riesbeck K, Singh B, Leo JC, Hammerschmidt S, Zipfel PF, Schütz MS (2017) Vitronectin Binds to a Specific Stretch within the Head Region of Yersinia Adhesin A and Thereby Modulates Yersinia enterocolitica Host Interaction. J Innate Immun 9(1), 33-51.

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Röttgerding F, Wagemakers A, Koetsveld J, Fingerle V, Kirschfink M, Hovius JW, Zipfel PF, Wallich R, Kraiczy P (2017) Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties. Sci Rep 7(1), 303.

Details

Buhlmann D^*, Eberhardt HU^*, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C ^*authors contributed equally (2016) FHR3 Blocks C3d-Mediated Coactivation of Human B Cells. J Immunol 197(2), 620-629.

Details

Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF (2016) Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces. J Am Soc Nephrol 27(5), 1413-1425.

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Hallström T, Singh B, Kraiczy P, Hammerschmidt S, Skerka C, Zipfel PF, Riesbeck K (2016) Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif. PLOS ONE 11(1), e0147709.

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Hammerschmidt H, Klevenhaus Y, Koenigs A, Hallström T, Fingerle V, Skerka C, Pos KM, Zipfel PF, Wallich R, Kraiczy P (2016) BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex. Mol Immunol 99, 407-424.

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Koenigs A, Stahl J, Averhoff B, Göttig S, Wichelhaus TA, Wallich R, Zipfel PF, Kraiczy P (2016) CipA of Acinetobacter baumannii Is a Novel Plasminogen Binding and Complement Inhibitory Protein J Infect Dis 213(9), 1388-1399.

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Olivar R, Luque A, Cárdenas-Brito S, Naranjo-Gómez M, Blom AM, Borràs1 F, Rodriguez de Córdoba S, Zipfel PF, Aran JM (2016) The complement inhibitor factor H generates an anti-inflammatory and tolerogenic state in monocyte-derived dendritic cells J Immunol 196(10), 4274-4290.

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Pollmächer J, Timme S, Schuster S, Brakhage AA, Zipfel PF, Figge MT (2016) Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs. Sci Rep 6, 27807.

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