(2023)
Synthesis of aryl- and alkyl-containing 3-methylene-5-hydroxy esters via a barbier allylation reaction.
Eur J Org Chem 26(18),
e202300177.
Prof. Dr. Christine Beemelmanns
Chemical Biology of Microbe-Host Interactions · Head +49 3641 532-1525 christine.beemelmanns@leibniz-hki.deCurriculum vitae
Main Research Areas
- Isolation and determination of the structure of signal molecules and antimicrobial natural products
- Characterisation of interactions between microbes and eucaryotes
- Total synthesis of natural products and chemical derivatisation
Professional Career
| since 01/2022 | Professor of Biochemistry of Microbial Metabolism at the University of Leipzig |
| Since 12/2013 | Junior group head at the Leibniz-Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute, Jena, chemical biology of microbe-host-interactions |
| 2011-2013 | Postdoc at the Harvard Medical School, Harvard University, supervisor: Prof. J. Clardy, BCMP, Department of Biomolecular Chemistry and Molecular Pharmacology |
| 2010-2011 | Postdoc at the Tokyo Institute of Technology, chemical faculty (Tokyo, Japan) supervisor: Prof. K. Suzuki |
| 2010 | Dr. rer. nat. in chemistry, summa cum laude, Freie Universität Berlin |
| 2007-2010 | PhD dissertation, organic chemistry instructed by Prof. H.-U. Reißig at the Freie Universität Berlin (Germany) |
| 2006-2007 | Research period at the RIKEN, chemistry, in the working group of Prof. M. Sodeoka (Japan) |
| 2001-2006 | Studies in chemistry, diploma at the RWTH Aachen (Germany) |
Awards · Appointments · Scientific Activities
| 2021 | Nachwuchswissenschaftler-Preise für Naturstoffforschung |
| 2020 | Dozentenpreis des Fonds der Chemischen Industrie |
| 2020 | Visiting Professor in Madison Wisconsin USA |
| 2019-2024 | ERC Starting GRant MORPHEUS |
| 2014-2015 | Postdoc fellowship from the Daimler and Benz Foundation and the Reinhard Frank Foundation |
| Since 2014 | Membership VAAM, FEMS and IUMS |
| Since 2014 | Membership Dechema |
| Since 2014 | Membership National Research Foundation of Korea |
| 2011-2013 | Postdoc fellowship from the Leopoldina Nationale Akademie der Wissenschaften; Postdoc fellowship from the DFG rejected |
| 2011 | Ernst-Reuter-Award of the Freie Universität Berlin; Ernst-Reuter-Gesellschaft der Freunde, Förderer und Ehemaligen der Freien Universität Berlin (Berlin, Germany) |
| 2010-2011 | Postdoc fellowship from the DAAD |
| Since 2010 | Member of the commission, Studienstiftung des deutschen Volkes |
| 2007-2010 | Networking fellowship for doctoral researchers at the Studienstiftung des deutschen Volkes |
| 2007-2009 | Doctoral fellowship funded by the Verband Chemischen Industrie (VCI) |
| 2006 | Springorum commemorative coin from the RWTH Aachen (Aachen, Germany) |
| 2006 | Procter and Gamble award, expert group chemistry at the RWTH Aachen |
| 2006-2007 | RIKEN fellowship from the Studienstiftung des deutschen Volkes |
| 2004-2006 | Studies in chemistry: fellowship from the Studienstiftung des deutschen Volkes |
| Since 2003 | Member of the GDCH |
| 2003 | Chemical award from the faculty for mathematics, informatics, natural sciences, RWTH Aachen |
| 2003 | Schöneborn award from the Gesellschaft der Freunde und Förderer der RWTH Aachen e.V., RWTH Aachen (Aachen, Germany) |
Publications
(2023)
Multiple mutations in the Nav1.4 sodium channel of New Guinean toxic birds provide autoresistance to deadly batrachotoxin.
Mol Ecol
[Epub ahead of print]
(2023)
Adaptations of Pseudoxylaria towards a comb-associated lifestyle in fungus-farming termite colonies.
ISME J 17(5),
733-747.
(2023)
Isolation, (bio)synthetic studies and evaluation of antimicrobial properties of drimenol-type sesquiterpenes of Termitomyces fungi.
Commun Chem 6(1),
79.
(2023)
Genome mining for macrolactam-encoding gene clusters allowed for the network-guided isolation of β-amino acid-containing cyclic derivatives and heterologous production of ciromicin A.
Commun Chem 6(1),
257.
(2022)
Biosynthesis of the sphingolipid inhibitors sphingofungins in filamentous fungi requires aminomalonate as a metabolic precursor.
ACS Chem Biol 17(2),
386-394.
(2022)
Synthesis of functionalized δ-hydroxy-β-keto esters and evaluation of their anti-inflammatory properties.
ChemBioChem 23(9),
e202200073.
(2022)
Insights into the metabolomic capacity of podaxis and isolation of podaxisterols A-D, ergosterol derivatives carrying nitrosyl cyanide-derived modifications.
J Nat Prod 85(9),
2159-2167.
(2022)
Signalling molecules inducing metamorphosis in marine organisms.
Nat Prod Rep 39(9),
1833-1855.
(Review)
(2022)
Desaturation of the sphingofungin polyketide tail results in increased serine palmitoyltransferase inhibition.
Microbiol Spectr 10(5),
e0133122.
