Dr. Freddy Alexander Bernal

Alumni

Publications

Jia LJ#, Bernal FA, Soehnlein J, Sonnberger J, Heineking I, Rafiq M, Cseresnyes Z, Kage F, Schmidt F, Zaher R, Hortschansky P, Chaudhary S, Gong X, Schirawski J, Figge MT, Hube B, Brakhage AA# (2025) Convergent evolution of a fungal effector enabling phagosome membrane penetration. bioRxiv [Preprint]
Keiff F, Bernal FA, Joch M, Jacques Dit Lapierre TJW, Li Y, Liebing P, Dahse HM, Vilotijevic I, Kloss F (2024) Modulation of the Meisenheimer complex metabolism of nitro-benzothiazinones by targeted C-6 substitution. Commun Chem 7(1), 153.
Torres-Gómez H, Keiff F, Hortschansky P, Bernal F, Kerndl V, Meyer F, Messerschmidt N, Dal Molin M, Krüger T, Rybniker J, Brakhage AA, Kloss F (2024) Replacement of the essential nitro group by electrophilic warheads towards nitro-free antimycobacterial benzothiazinones. Eur J Med Chem 279, 116849.
Keiff F, Jacques dit Lapierrev TJW, Bernal F, Kloss F (2023) Design and synthesis of benzofuran- and naphthalene-fused thiazinones as antimycobacterial agents. Arch Pharm (Weinheim) 356(11), e2300356.
Bernal FA, Coy-Barrera E (2022) Composition and antifungal activity of the alkaloidal fraction of Lupinus mirabilis leaves: A biochemometrics-based exploration. Molecules 27(9), 2832.
Bernal FA, Hammann P, Kloss F (2022) Natural products in antibiotic development: is the success story over? Curr Opin Biotechnol 78, 102783. (Review)
Schieferdecker S, Bernal FA, Wojtas KP, Keiff F, Li Y, Dahse HM, Kloss F (2022) Development of predictive classification models for whole cell antimycobacterial activity of benzothiazinones. J Med Chem 65(9), 6748-6763.
Bernal FA, Gerhards M, Kaiser M, Wünsch B, Schmidt TJ (2020) (±)-trans-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: Synthesis, in vitro evaluation and SAR analysis. Eur J Med Chem 205, 112493.
Bernal FA, Kaiser M, Wünsch B, Schmidt TJ (2020) Structure-activity relationships of cinnamate ester analogues as potent antiprotozoal agents. ChemMedChem 15(1), 68-78.
Martin B, Schepmann D, Bernal FA, Schmidt TJ, Che T, Loser K, Wünsch B (2020) Enantiomerically pure quinoline-based κ-opioid receptor agonists: Chemoenzymatic synthesis and pharmacological evaluation. ChemMedChem 15(15), 1408-1420.