(2023) Tuning the corona-core ratio of polyplex micelles for selective oligonucleotide delivery to hepatocytes or hepatic immune cells. Biomaterials 294, 122016.
Main Research Areas
- Host-pathogen interaction on human pathogenic fungi
- Automated processing of microscopic images
- Spatiotemporal computer simulations of agent-based infection models
|since 2021||Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena|
|since 2011||Head of Research Group Applied Systems Biology, Leibniz-HKI|
|2011-2021||Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena|
|2005-2010||Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt|
|2001-2005||Research assistant in Computer Physics at the University Groningen (NL)|
|2000||Dr. rer. nat. in Physics at the University Groningen (NL)|
|1995||Diploma in Physics at the University Dortmund|
Awards · Appointments · Scientific Activities
|2011 - 2017||Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS)|
Scientific Activities and Functions
|since 2021||Deputy Coordinator of the Jena School for Microbial Communication|
|since 2019||Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse”|
|Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse”|
|since 2019||Speaker of Leibniz ScienceCampus “InfectoOptics”|
|since 2019||Editor: Scientific Reports|
|since 2017||Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology|
|since 2017||PI and member of the DFG-Collaborative Research Center 1278 PolyTarget|
|since 2017||Editor: Cytometry A|
|since 2015||Member: Jena Center for Soft Matter|
|since 2015||Member: Michael Stifel Center for Data-Driven and Simulation Science|
|since 2014||PI and member of the DFG-Collaborative Research Center 124 FungiNet|
|since 2014||Editor: Computational and Mathematical Models in Medicine|
|since 2012||Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB)|
|since 2011||Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI)|
|since 2011||Member: International Leibniz Research School for Microbial and Biomolecular Interactions|
|since 2011||Member: Jena School for Microbial Communication|
(2023) The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus. mSphere 8(8), e0052322.
(2023) Targeting of phagolysosomes containing conidia of the human pathogenic fungus Aspergillus fumigatus with polymeric particles. Appl Microbiol Biotechnol 107(2-3), 819-834.
(2023) Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway. Cell Host Microbe 31(3), 373-388.
(2023) Analysis of HDACi-coupled nanoparticles: Opportunities and challenges. In: Humana, New York, NY (eds.) HDAC/HAT Function Assessment and Inhibitor Development. Methods in Molecular Biology 2589, pp. 129-144. Springer Protocols. ISBN: 978-1-0716-2787. (Review)
(2023) Guided-deconvolution for correlative light and electron microscopy. PLOS One 18(3), e0282803.
(2023) Polymer-based particles against pathogenic fungi: A non-uptake delivery of compounds. Biomater Adv 146, 213300.
(2023) Sodium thiosulfate refuels the hepatic antioxidant pool reducing ischemia-reperfusion-induced liver injury. Free Radic Biol Med 204, 151-160.
(2023) Surrogate infection model predicts optimal alveolar macrophage number for clearance of Aspergillus fumigatus infections. NPJ Syst Biol Appl 9, 12.