(2011)
Modelling Intravital Two-Photon Data of Lymphocyte Migration and Interaction
In: Molina-París C, Lythe G (eds.) Mathematical Models and Immune Cell Biology pp. 121-139. Springer, Heidelberg.
ISBN: 978-1-4419-7724.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction of human pathogenic fungi
- Automated processing of microscopic images and spectroscopy data
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
| since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
| since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
| 2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
| 2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
| 2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
| 2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
| 1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
| 2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Appointments and Scientific Activities
| since 2023 | Board Member and Coordinator of Task Area “Bioimage Informatics” in the DFG-funded national research data management initiative “NFDI4Bioimage” |
| since 2023 | Board Member and PI in the DFG-Research Training School RTG 2723 – “Materials-Microbes-Microenvironments” |
| since 2023 | Board Member of the Beutenberg Campus e.V. “Life Science meets Physics” |
| since 2023 | Editor: PLOS Complex Systems |
| since 2023 | Editor: Biological Imaging |
| since 2022 | Coordinator of Basic Technology 3 in the BMBF-funded “Leibniz Center for Photonics in Infection Research” |
| since 2022 | Coordinator of the BMBF-funded "Multi-Model-Simulator Project” in the funding line “Computational Life Sciences” |
| since 2021 | Deputy Coordinator of the "Jena School for Microbial Communication" |
| since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
| since 2019 | Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” |
| since 2019 | Speaker and PI of Leibniz ScienceCampus “InfectoOptics” |
| since 2019 | Editor: Scientific Reports |
| since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
| since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
| since 2017 | Editor: Cytometry A |
| since 2015 | Member: Jena Center for Soft Matter |
| since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
| since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
| since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
| since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
| since 2011 | Faculty member and PI in the "International Leibniz Research School for Microbial and Biomolecular Interactions" |
| since 2011 | Faculty member and PI in the "Jena School for Microbial Communication" |
Publications
(2011)
Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus.
PLOS ONE 6(5),
e19591, *authors contributed equally.
(2010)
Modelling cellular aggregation induced by chemotaxis and phototaxis.
Math Med Biol 27(4),
373-384.
(2010)
Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.
Immunity 33(1),
84-95.
(2009)
Optimization of immunoglobulin substitution therapy by a stochastic immune response model.
PLOS ONE 4(5),
e5685.
(2009)
Modeling receptor-ligand binding kinetics in immunological synapse formation.
The European Physical Journal D 51(1),
153-160.
(2009)
Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: a systems biology approach.
Arthritis Rheum 60(9),
2585-2594.
(2009)
Germinal centres seen through the mathematical eye: B-cell models on the catwalk.
Trends Immunol 30(4),
157-164.
(2008)
Deriving a germinal center lymphocyte migration model from two-photon data.
J Exp Med 205(13),
3019-3029.
(2006)
Geometrically repatterned immunological synapses uncover formation mechanisms.
PLOS Comput Biol 2(11),
e171.
