(2020)
Staphylococcus aureus lung infection results in down-regulation of surfactant protein-A mainly caused by pro-inflammatory macrophages.
Microorganisms 8(4),
577.
Curriculum vitae
Main Research Areas
- Host-pathogen interaction of human pathogenic fungi
- Automated processing of microscopic images and spectroscopy data
- Spatiotemporal computer simulations of agent-based infection models
Professional Career
| since 2021 | Professor (W3) for Applied Systems Biology, Friedrich Schiller University Jena |
| since 2011 | Head of Research Group Applied Systems Biology, Leibniz-HKI |
| 2011-2021 | Professor (W2) for Applied Systems Biology, Friedrich Schiller University Jena |
| 2005-2010 | Junior Fellow in Theoretical Immunology at the Frankfurt Institute for Advanced Studies (FIAS) of the Goethe University Frankfurt |
| 2001-2005 | Research assistant in Computer Physics at the University Groningen (NL) |
| 2000 | Dr. rer. nat. in Physics at the University Groningen (NL) |
| 1995 | Diploma in Physics at the University Dortmund |
Awards · Appointments · Scientific Activities
Awards
| 2011 - 2017 | Adjunct Fellow at Frankfurt Institute for Advanced Studies (FIAS) |
Appointments and Scientific Activities
| since 2023 | Board Member and Coordinator of Task Area “Bioimage Informatics” in the DFG-funded national research data management initiative “NFDI4Bioimage” |
| since 2023 | Board Member and PI in the DFG-Research Training School RTG 2723 – “Materials-Microbes-Microenvironments” |
| since 2023 | Board Member of the Beutenberg Campus e.V. “Life Science meets Physics” |
| since 2023 | Editor: PLOS Complex Systems |
| since 2023 | Editor: Biological Imaging |
| since 2022 | Coordinator of Basic Technology 3 in the BMBF-funded “Leibniz Center for Photonics in Infection Research” |
| since 2022 | Coordinator of the BMBF-funded "Multi-Model-Simulator Project” in the funding line “Computational Life Sciences” |
| since 2021 | Deputy Coordinator of the "Jena School for Microbial Communication" |
| since 2019 | Coordinator of Research Area C – Data Synopsis in the Excellence Cluster “Balance of the Microverse” |
| since 2019 | Member of the Management Board of the Microverse Imaging Center in the Excellence Cluster “Balance of the Microverse” |
| since 2019 | Speaker and PI of Leibniz ScienceCampus “InfectoOptics” |
| since 2019 | Editor: Scientific Reports |
| since 2017 | Ombudsperson at the Leibniz Institute for Natural Product Research and Infection Biology |
| since 2017 | PI and member of the DFG-Collaborative Research Center 1278 PolyTarget |
| since 2017 | Editor: Cytometry A |
| since 2015 | Member: Jena Center for Soft Matter |
| since 2015 | Member: Michael Stifel Center for Data-Driven and Simulation Science |
| since 2014 | PI and member of the DFG-Collaborative Research Center 124 FungiNet |
| since 2012 | Organizer: Biennial international symposium on “Image-based Systems Biology” (IbSB) |
| since 2011 | Organizer: Biennial international symposium on “Systems Biology of Microbial Infection” (SBMI) |
| since 2011 | Faculty member and PI in the "International Leibniz Research School for Microbial and Biomolecular Interactions" |
| since 2011 | Faculty member and PI in the "Jena School for Microbial Communication" |
Publications
(2020)
Flotillin-dependent lipid-raft microdomains are required for functional phagolysosomes against fungal infections.
Cell Rep 32(7),
108017.
(2020)
Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus.
mBio 11(2),
e00596-20.
(2020)
Dynamic interplay of host and pathogens in an avian whole blood model.
Front Immunol 11,
500.
(2020)
Quantification of factor H mediated self versus non-self discrimination by mathematical modeling.
Front Immunol 11,
1911.
(2019)
Automated tracking of label-free cells with enhanced recognition of whole tracks.
Sci Rep 9(1),
3317.
(2019)
Comparative assessment of aspergillosis by virtual infection modeling in murine and human lung.
Front Immunol 10,
142.
(2019)
Enolase from Aspergillus fumigatus is a moonlighting and immune evasion protein that binds the human plasma complement proteins factor H, FHL-1, C4BP, and plasminogen.
Front Immunol 10,
2573.
(2019)
The geographical region of origin determines the phagocytic vulnerability of Lichtheimia strains.
Environ Microbiol 21(12),
4563-4581.
(2019)
Regulation of the germinal center reaction and somatic hypermutation dynamics by homologous recombination.
J Immunol 203(6),
1493-1501.
