Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.

Wilson D, Hebecker B, Moyes DL, Miramón P, Jablonowski N, Wisgott S, Allert S, Naglik JR, Hube B (2013) Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection. Antimicrob Agents Chemother 57(10), 5178-5180.

Abstract

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a

Leibniz-HKI-Authors

Bernhard Hube
Stefanie Allert
Betty Hebecker
Nadja Jablonowski
Stephanie Wisgott
Duncan Wilson
Pedro Miramón

Identifier

doi: 10.1128/AAC.01244-13

PMID: 23896471