Microbial Pathogenicity Mechanisms

Schimanski J, Gresnigt MS, Brunner E, Werz O, Hube B, Garscha U (2024) Hyphal-associated protein expression is crucial for Candida albicans-induced eicosanoid biosynthesis in immune cells. Eur J Immunol 54(3), e2350743.

Sekeresova Kralova J, Donic C, Dassa B, Livyatan I, Jansen PM, Ben-Dor S, Fidel L, Trzebanski S, Narunsky-Haziza L, Asraf O, Brenner O, Dafni H, Jona G, Boura-Halfon S, Stettner N, Segal E, Brunke S, Pilpel Y, Straussman R, Zeevi D, Bacher P, Hube B, Shlezinger N, Jung S (2024) Competitive fungal commensalism mitigates candidiasis pathology. J Exp Med 221(5), e20231686.

Sprague JL, Schille TB, Allert S, Trümper V, Lier A, Großmann P, Priest EL, Tsavou A, Panagiotou G, Naglik JR, Wilson D, Schäuble S, Kasper L^*, Hube B^*# (2024) Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκBmediated barrier protection. PLOS Pathog 20(3), e1012031.

Stanca SE, Mogavero S, Fritzsche W, Krafft C, Hube B, Popp J (2024) Isotope labeled 3D-Raman confocal imaging and atomic force microscopy study on epithelial cells interacting with the fungus Candida albicans. Nanomedicine 59, 102750.

Valentine M^*, Rudolph P^*, Dietschmann A, Tsavou A, Mogavero S, Lee S, Priest EL, Zhurgenbayeva G, Jablonowski N, Timme S, Eggeling C, Allert S, Dolk E, Naglik JR, Figge MT, Gresnigt MS^*#, Hube B^*# (2024) Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis. mBio 15(3), e0340923.

Wickramasinghe DN, Lyon CM, Lee S, Hepworth OW, Priest EL, Maufrais C, Ryan AP, Permal E, Sullivan D, McManus BA, Hube B, Butler G, d'Enfert C, Naglik JR, Richardson JP (2024) Variations in candidalysin amino acid sequence influence toxicity and host responses. mBio 15(8), e0335123.

Alings F, Scharmann K, Eggers C, Böttcher B, Sokołowski M, Shvetsova E, Sharma P, Roth J, Rashiti L, Glatt S, Brunke S, Leidel SA (2023) Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA. Nucleic Acids Res 51(15), 8133-8149.

Brandt P^*, Mirhakkak MH^*, Wagner L, Driesch D, Möslinger A, Fänder P, Schäuble S, Panagiotou G, Vylkova S^# (2023) High-throughput profiling of Candida auris isolates reveals clade-specific metabolic differences. Microbiol Spectr 11(3), e0049823. (Review)

Case NT, Westman J, Hallett MT, Plumb J, Farheen A, Maxson ME, MacAlpine J, Liston SD, Hube B, Robbins N, Whitesell L, Grinstein S, Cowen LE (2023) Respiration supports intraphagosomal filamentation and escape of Candida albicans from macrophages. mBio 14(6), e0274523.

Götze S, Vij R, Burow K, Thome N, Urbat L, Schlosser N, Pflanze S, Müller R, Hänsch VG, Schlabach K, Fazlikhani L, Walther G, Dahse HM, Regestein L, Brunke S, Hube B, Hertweck C, Franken P, Stallforth P (2023) Ecological niche-inspired genome mining leads to the discovery of crop-protecting nonribosomal lipopeptides featuring a transient amino acid building block. J Am Chem Soc 145(4), 2342-2353.