Dr. Mark Sebastiaan Gresnigt
Adaptive Pathogenicity Strategies · Head Microbial Pathogenicity Mechanisms · Humboldt Research Fellowship
Phone: +49 3641 532-1305 Fax: +49 3641 532-0810 Email: email@example.com
|Since 05/2018||Postdoctoral researcher, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms|
|03/2018-04/2018||Language Course German, Dresden, Germany|
|08/2015-03/2018||Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen institute for infectious diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections|
|10/2010-05/2015||Phd, Radboud University Nijmegen Medical centre, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus|
|02/2008-08/2010||M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands|
|07/2003-07/2007||B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands|
Awards · Appointments · Scientific Activities
|2018||Humboldt Research Fellowship for Postdoctoral Researchers|
|2018||Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center|
|2016||3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS)|
|2015||Prize for best PhD thesis by the Dutch society for Immunology (NVVI)|
|2015||Youth development Prize by the German speaking society for Mycology (DMykG)|
|2013||ALLFUN Investigators Award|
(2019) The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity. Cell Metab 29(1), 211-220.e5.
(2019) Keeping Candida commensal: How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model. Dis Model Mech 12(9), pii: dmm039719.
(2019) Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst. J Leukoc Biol 106(1), 11-25.
(2019) A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans. J Infect Dis 220(5), 862-872.
(2019) A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis. Sci Transl Med 11(496), pii: eaar3558.
(2019) A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies. Biomaterials 220, 119396.
(2018) Adjunctive interferon-γ immunotherapy in a pediatric case of Aspergillus terreus infection. Eur J Clin Microbiol Infect Dis [Accepted]
(2018) Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. Nat Commun 9(1), 2636.
(2018) The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun 9(1), 4260.