(2019)
The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity.
Cell Metab 29(1),
211-220.e5.

Dr. Mark Gresnigt
Adaptive Pathogenicity Strategies · Head +49 3641 532-1305 mark.gresnigt@leibniz-hki.deCurriculum vitae
Main Research Areas
- Infection biology of human pathogenic fungi (Candida albicans)
- Immunology of fungal infections
- Host-pathogen interactions
- Fungal adaptation to the host
Professional Career
Since 05/2020 |
Junior Research Group Leader, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Adaptive Pathogenicity Strategies |
05/2018- 05/2020 |
Alexander von Humboldt Foundation Postdoctoral Fellowship, Leibniz Institute of Natural Product Research and Infection Biology - Hans Knoell Institute, Dept. Microbial Pathogenicity Mechanisms |
03/2018-04/2018 | Language Course German, Dresden, Germany |
08/2015-03/2018 | Postdoctoral researcher, Radboud University Medical Center, Department of Internal medicine, Nijmegen Institute for Infectious Diseases. Project: The development of novel immunomodulatory strategies for disseminated fungal infections |
10/2010-05/2015 | Phd, Radboud University Nijmegen Medical Center, department of internal medicine, Nijmegen, The Netherlands. Project: Pattern recognition and cytokine signalling pathways in the host defence against Aspergillus fumigatus |
02/2008-08/2010 | M.Sc. Medical Biology, Radboud University, Nijmegen, The Netherlands |
07/2003-07/2007 | B.Sc. Biology and Medical Laboratory Research, Saxion University of Applied Sciences, Enschede, The Netherlands |
Awards · Appointments · Scientific Activities
2021 | Research award of the German speaking society for Mycology (DMykG) |
2021 | Science Award Life Sciences and Physics 2021 Beutenberg Campus e.V. Jena |
Since 2021 | Member and PI of the DFG SFB/TR 124 programme "Pathogenic fungi and their human host: Networks of interaction – FungiNet'" |
Since 2020 | DFG Emmy Noether grant |
2020 | Journal of Fungi Travel Award |
2020 | Co-Organizer of the FEBS advanced practical course “State-of-the-art infection models for human pathogenic fungi” in Jena, Germany |
2019 | PLoS Pathogens Postdoctoral Poster Award, Advanced lecture course on Human Fungal Pathogens |
2019 | ESCMID Research Grant 2019 |
2019 | Co-organizer of the winter school of the FunHoMic Marie Curie International Training Network |
2018-2021 | Two publication awards of the Deutschsprachigen Mykologischen Gesellschaft (DMykG; as co-author) |
2018 | Humboldt Research Fellowship for Postdoctoral Researchers |
2018 | Golden pipette award by the Laboratory for Experimental Internal Medicine Radboud University Nijmegen Medical center |
2016 | 3rd prize for best thesis by the Radboud institute for molecular life sciences (RIMLS) |
2015 | Van Beckum thesis Award for best PhD thesis in the field of immunology by the Dutch society for Immunology (NVVI) |
2015 | Youth development Prize by the German speaking society for Mycology (DMykG) |
Since 2014 | Ad hoc reviewer for 19 journals eLife, PLoS Pathogens, mBio, Journal of Infectious Diseases, Frontiers Immunology, Cellular Microbiology, FEMS microbiology letters, Microbial Pathogenesis, Virulence, and others |
2013 | ALLFUN Investigators Award |
Publications
(2019)
Keeping Candida commensal: How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model.
Dis Model Mech 12(9),
dmm039719.
(2019)
Frontline science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst.
J Leukoc Biol 106(1),
11-25.
(2019)
A genome-wide functional genomics approach identifies susceptibility pathways to fungal bloodstream infection in humans.
J Infect Dis 220(5),
862-872.
(2019)
A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis.
Sci Transl Med 11(496),
eaar3558.
(2019)
A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies.
Biomaterials 220,
119396.
(2018)
Adjunctive interferon-γ immunotherapy in a pediatric case of Aspergillus terreus infection.
Eur J Clin Microbiol Infect Dis 37(10),
1915-1922.
(2018)
Differential Kinetics of Aspergillus nidulans and Aspergillus fumigatus Phagocytosis.
J Innate Immun 10(2),
145-160.
(2018)
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis.
Nat Commun 9(1),
2636.
(2018)
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes.
Nat Commun 9(1),
4260.