(2025)
A droplet microfluidic strategy for cultivation, investigation, and high-throughput isolation of mouse gut microbiome bacteria.
Appl Environ Microbiol 91(8),
e0069525.
Prof. Dr. Ilse Denise Jacobsen
Microbial Immunology · Head Deputy Director +49 3641 532-1223 ilse.jacobsen@leibniz-hki.deCurriculum vitae
Main Research Areas
- Immunology and infection biology of pathogenic fungi
- In vivo and ex vivo infection models
- Mucosal pathogen-host-interaction
Professional Career
| since 2014 | Professor for Microbial Immunology, FSU Jena |
| since 2013 | Head of the research group "Microbial Immunology", HKI Jena |
| 2013 | Habilitation and Venia legendi in microbiology, Friedrich-Schiller-University Jena |
| 2007-2013 | Head of the working group "Infection Models" within the department of Microbial Pathogenicity Mechanisms, HKI Jena, Deputy Supervisor |
| 2007 | Veterinary surgeon specialising in microbiology |
| 2005-2007 | Research assistant (postdoc) at the Institute for Microbiology, University of Veterinary Medicine, Hanover, within the SFB 587 (immune reaction of the lungs in case of infection and allergy, project A4) |
| 2002-2005 | PhD studies at the University of Veterinary Medicine, Hanover, project: "molecular mechanisms of the adaptation of Actinobacillus pleuropneumoniae to the respiratory tract of pigs" (DFG Research Training Group 745: Mucosal host-pathogen-interaction), PhD degree summa cum laude |
| 2001 | Veterinary license |
| 1995-2001 | Studies in veterinary medicine in Hanover and Pretoria, South Africa |
Awards · Appointments · Scientific Activities
| since 2013 | Note taker within the specialist group "eukaryotic pathogens", Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM) |
| 2013 | Co-organiser FEBS Advanced Practical Course "state-of-the-art infection models for human pathogenic fungi" |
| since 2012 | Academic editor for PLoS One and Medical Mycology Case Reports |
| 2010-2013 | Deputy member of the advisory panel in accordance with § 15 clause 1 Animal Welfare Act, Thuringia |
| 2007 | Partial fellowship for taking part in the course molecular mycology: current approaches to fungal pathogenesis, Woods Hole, USA |
| 2005 | Award in veterinary medicine from the Kurt-Alten-Foundation for the best PhD-thesis |
| 2001-2004 | Fellow at the DFG’s research training group 745 |
| 2000 | Full fellowship (The Wellcome Trust) at the summer school: fundamentals of veterinary science, University of Cambridge, UK |
| 1998 | Awards from the H. Wilhelm Schaumann Stiftung zu Hamburg for the best student achievements |
| 1995-2001 | Fellow at the Studienstiftung des deutschen Volkes |
Publications
(2025)
Synergistic interactions between Candida albicans and Enterococcus faecalis promote toxin-dependent host cell damage.
Proc Natl Acad Sci U S A 122(46),
e2505310122.
(2025)
Identification of a fungal antibacterial endopeptidase that cleaves peptidoglycan.
EMBO Rep 26(1),
3889-3916.
(2025)
The murine lung microbiome is disbalanced by the human-pathogenic fungus Aspergillus fumigatus resulting in enrichment of anaerobic bacteria.
Cell Rep 44(3),
115442.
(2024)
A highly conserved tRNA modification contributes to C. albicans filamentation and virulence.
Microbiol Spectr 12(5),
e0425522.
(2024)
Infection models for human pathogenic fungi.
In: Brakhage AA, Kniemeyer O, Zipfel PF (eds.) The Mycota - Human and Animal Relationships 3. 6, pp. 193-206. Springer, Cham.
ISBN: 978-3-031-64853. (Review)
(2023)
The role of host and fungal factors in the commensal-to-pathogen transition of Candida albicans.
Curr Clin Micro Rpt 10(2),
55-65.
(Review)
(2023)
Mouse models of Mucormycosis.
Methods Mol Biol 2667,
181-196.
(Review)
(2023)
Soluble enolase 1 of Candida albicans and Aspergillus fumigatus stimulates human and mouse B cells and monocytes.
J Immunol 211(5),
804-815.
(2023)
Escherichia coli nissle 1917 antagonizes Candida albicans growth and protects intestinal cells from C. albicans-mediated damage.
Microorganisms 11(8),
1929.
