(2020)
Proteome analysis of bronchoalveolar lavage fluids reveals host and fungal proteins highly expressed during invasive pulmonary aspergillosis in mice and humans.
Virulence 11(1),
1337-1351.
Prof. Dr. Ilse Denise Jacobsen
Microbial Immunology · Head Deputy Director +49 3641 532-1223 ilse.jacobsen@leibniz-hki.deCurriculum vitae
Main Research Areas
- Immunology and infection biology of pathogenic fungi
- In vivo and ex vivo infection models
- Mucosal pathogen-host-interaction
Professional Career
| since 2014 | Professor for Microbial Immunology, FSU Jena |
| since 2013 | Head of the research group "Microbial Immunology", HKI Jena |
| 2013 | Habilitation and Venia legendi in microbiology, Friedrich-Schiller-University Jena |
| 2007-2013 | Head of the working group "Infection Models" within the department of Microbial Pathogenicity Mechanisms, HKI Jena, Deputy Supervisor |
| 2007 | Veterinary surgeon specialising in microbiology |
| 2005-2007 | Research assistant (postdoc) at the Institute for Microbiology, University of Veterinary Medicine, Hanover, within the SFB 587 (immune reaction of the lungs in case of infection and allergy, project A4) |
| 2002-2005 | PhD studies at the University of Veterinary Medicine, Hanover, project: "molecular mechanisms of the adaptation of Actinobacillus pleuropneumoniae to the respiratory tract of pigs" (DFG Research Training Group 745: Mucosal host-pathogen-interaction), PhD degree summa cum laude |
| 2001 | Veterinary license |
| 1995-2001 | Studies in veterinary medicine in Hanover and Pretoria, South Africa |
Awards · Appointments · Scientific Activities
| since 2013 | Note taker within the specialist group "eukaryotic pathogens", Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM) |
| 2013 | Co-organiser FEBS Advanced Practical Course "state-of-the-art infection models for human pathogenic fungi" |
| since 2012 | Academic editor for PLoS One and Medical Mycology Case Reports |
| 2010-2013 | Deputy member of the advisory panel in accordance with § 15 clause 1 Animal Welfare Act, Thuringia |
| 2007 | Partial fellowship for taking part in the course molecular mycology: current approaches to fungal pathogenesis, Woods Hole, USA |
| 2005 | Award in veterinary medicine from the Kurt-Alten-Foundation for the best PhD-thesis |
| 2001-2004 | Fellow at the DFG’s research training group 745 |
| 2000 | Full fellowship (The Wellcome Trust) at the summer school: fundamentals of veterinary science, University of Cambridge, UK |
| 1998 | Awards from the H. Wilhelm Schaumann Stiftung zu Hamburg for the best student achievements |
| 1995-2001 | Fellow at the Studienstiftung des deutschen Volkes |
Publications
(2020)
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments.
J Clin Invest 130(9),
4587-4600.
(2020)
Ahr1 and Tup1 contribute to the transcriptional control of virulence-associated genes in Candida albicans.
mBio 11(2),
e00206-20.
(2020)
Fungal biotin homeostasis is essential for immune evasion after macrophage phagocytosis and virulence.
Cell Microbiol 22(7),
e13197.
(2020)
Dynamic interplay of host and pathogens in an avian whole blood model.
Front Immunol 11,
500.
(2020)
Active neutrophil responses counteract Candida albicans burn wound infection of ex vivo human skin explants.
Sci Rep 10(1),
21818.
(2019)
Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils.
Nat Immunol 20(5),
546-558.
(2019)
Fungal infection strategies.
Virulence 10(1),
835-839.
(Review)
(2019)
Animal models to study mucormycosis.
J Fungi (Basel) 5(2),
27.
(Review)
(2019)
Unaltered fungal burden and ethality in human CEACAM1-transgenic mice during Candida albicans dissemination and systemic infection.
Front Microbiol 10,
2703.
