(2014) One small step for a yeast - Microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation. PLOS Pathog 10(10), e1004478.
Prof. Dr. Ilse Denise JacobsenMicrobial Immunology · Head Deputy Director +49 3641 532-1223 firstname.lastname@example.org
Main Research Areas
- Immunology and infection biology of pathogenic fungi
- In vivo and ex vivo infection models
- Mucosal pathogen-host-interaction
|since 2014||Professor for Microbial Immunology, FSU Jena|
|since 2013||Head of the research group "Microbial Immunology", HKI Jena|
|2013||Habilitation and Venia legendi in microbiology, Friedrich-Schiller-University Jena|
|2007-2013||Head of the working group "Infection Models" within the department of Microbial Pathogenicity Mechanisms, HKI Jena, Deputy Supervisor|
|2007||Veterinary surgeon specialising in microbiology|
|2005-2007||Research assistant (postdoc) at the Institute for Microbiology, University of Veterinary Medicine, Hanover, within the SFB 587 (immune reaction of the lungs in case of infection and allergy, project A4)|
|2002-2005||PhD studies at the University of Veterinary Medicine, Hanover, project: "molecular mechanisms of the adaptation of Actinobacillus pleuropneumoniae to the respiratory tract of pigs" (DFG Research Training Group 745: Mucosal host-pathogen-interaction), PhD degree summa cum laude|
|1995-2001||Studies in veterinary medicine in Hanover and Pretoria, South Africa|
Awards · Appointments · Scientific Activities
|since 2013||Note taker within the specialist group "eukaryotic pathogens", Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM)|
|2013||Co-organiser FEBS Advanced Practical Course "state-of-the-art infection models for human pathogenic fungi"|
|since 2012||Academic editor for PLoS One and Medical Mycology Case Reports|
|2010-2013||Deputy member of the advisory panel in accordance with § 15 clause 1 Animal Welfare Act, Thuringia|
|2007||Partial fellowship for taking part in the course molecular mycology: current approaches to fungal pathogenesis, Woods Hole, USA|
|2005||Award in veterinary medicine from the Kurt-Alten-Foundation for the best PhD-thesis|
|2001-2004||Fellow at the DFG’s research training group 745|
|2000||Full fellowship (The Wellcome Trust) at the summer school: fundamentals of veterinary science, University of Cambridge, UK|
|1998||Awards from the H. Wilhelm Schaumann Stiftung zu Hamburg for the best student achievements|
|1995-2001||Fellow at the Studienstiftung des deutschen Volkes|
(2014) Pathogenicity mechanisms and host response during oral Candida albicans infections. Expert Rev Anti Infect Ther 12(7), 867-879. (Review)
(2014) Galleria mellonella as a model host to study virulence of Candida. Virulence 5(2), 237-239.
(2014) In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy. J Antimicrob Chemother 69(10), 2785-2796.
(2014) NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens. Eur J Immunol 44(3), 662-672.
(2014) Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as important contributor to hypoxic survival. Eukaryot Cell 13(9), 1241-1253.
(2014) A family of glutathione peroxidases contributes to oxidative stress resistance in Candida albicans. Med Mycol 52(3), 223-239.
(2014) Candida albicans utilizes a modified β-oxidation pathway for the degradation of toxic propionyl-CoA. J Biol Chem 289(12), 8151-8169.
(2014) Differential role of NK cells against Candida albicans infection in immunocompetent or immunocompromised mice. Eur J Immunol 44(8), 2405-2414.
(2014) The pathogenic potential of the Lichtheimia genus revisited: Lichtheimia brasiliensis is a novel, non-pathogenic species. Mycoses 57(Suppl. 3), 128-131.