Systemsbiology of sepsis

Our main focus is to improve diagnosis and therapy of sepsis by functional genome analysis. We aim to understand the molecular context employing network based models. We are part of the Integrated Research and Treatment Center of Sepsis Control and Care (IFB CSCC) and are supported by the BMBF.

Further medical applications

Employing our methods, we investigate the regulation of the inflammatory response of immune cells after infection, aberrant regulatory mechanisms of metabolism in tumor cells, and are interested in telomere maintenance mechanisms.

Methods development

High throughput methods of functional genomics produce massive data on a genome wide scale for a large variety of different organisms, organs and diseases. This information needs to be funneled and organized into a medical meaningful context.

  • Regulation analysis: We specify gene regulation by e.g. combining the regulatory impact of different transcription factors, and estimate cell context specific regulation of transcription factors using mixed integer linear programming.
  • Alternative Splicing: We develop methods to identify alternative splicing using RNA-Seq data.
  • Pattern recognition in networks: We develop methods to detect specific regulation patterns in cellular networks using Wavelet transforms.