Analysing gene regulatory networks of neuroectodermal tumours

Frequent aberrations in neuroectodermal tumours (NET) are, among others, the over-expression or deregulation of c-Myc or MYCN as the consequence of an amplification of genetic material. The aim of our project is the reconstruction of target gene networks of such pathways both for mRNAs and for miRNAs. A network reconstruction is being carried out with a large number of gene expression profiles that also reach across tumours.