Tiny bodyguards

Helper bacteria stop and disarm pathogens

Mixed culture of the fungal pathogen Pseudomonas tolaasii and the helper bacterium Mycetocola tolaasinivorans. | Source Leibniz-HKI

The bacterium Pseudomonas tolaasii triggers brown spot disease in cultivated mushrooms and thus causes considerable harvest losses. The active compound Tolaasin, which is produced by the pathogen, damages the cell membrane of the fungus and the cells die. But with some support the fungus can resist: Bacteria of the genus Mycetocola inactivate both the toxic Tolaasin as well as another active compound that makes the pathogen mobile and enables its spread. A team of researchers from the Leibniz-HKI took a closer look at the molecular mechanism of the microbial triangle. The protective principle discovered in the process could serve as a model for applications in agriculture or medicine.

Involved Scientists at Leibniz-HKI

Christian Hertweck

Prof. Dr. Christian Hertweck

Phone: +49 3641 532-1101 Email: christian.hertweck@leibniz-hki.de

Ron Hermenau

Ron Hermenau

Phone: +49 3641 532-1563 Email: ron.hermenau@leibniz-hki.de

Susann Kugel (in Elternzeit)

Susann Kugel (in Elternzeit)

Anna Komor

Dr. Anna Komor

Phone: +49 3641 532-1357 Email: anna.komor@leibniz-hki.de

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