Immune defense against Candida Infections: Publication in Nature Microbiology
Infections caused by yeasts of the genus Candida trigger an immune response that was previously known only in the defense against viruses, bacteria or parasites. A research team from Jena and Barcelona identified a mechanism involving mitochondrial DNA signaling that could help treat the infection, as the scientists report in the journal Nature Microbiology.
Pekmezovic M, Hovhannisyan H, Gresnigt MS, Iracane E, Oliveira-Pacheco J, Siscar-Lewin S, Seemann E, Qualmann B, Kalkreuter T, Müller S, Kamradt T, Mogavero S, Brunke S, Butler G, Gabaldón T, Hube B (2021) Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells. Nature Microbiology doi.org/10.1038/s41564-021-00875-2