Oxidative stress defence

Reactive oxygen species (ROS) play an important role in almost all host-pathogen relationships. In the case of infection with Aspergillus fumigatus, this is particularly obvious: Patients with a genetic defect in superoxide formation (O2¯) are especially vulnerable to the often life-threatening invasive aspergillosis (IA). Phagocytes of the immune system are the major producers of O2¯. We are interested whether phagocyte derived ROS could pose a threat to fungi and if the ROS defense strategies may have been "trained" by microbial interactions.