New publication in Organic Letters
| by Annett Fischer
We congratulate all authors of a paper, which was published together with the Friedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry. The title is "Semiautomated Total Synthesis of the Cyclic Lipodepsipeptide Anikasin" it was published in Organic Letters!
Abstract: The total synthesis of Pseudomonas-derived cyclic lipodepsipeptide anikasin was achieved. Using a depsipeptide building block and balanced protecting groups on the branching d-allo-Thr residue, the synthesis was established semiautomatically on a synthesizer. Buffered deprotections minimized side reactions and afforded synthetic anikasin and its enantiomer. Biological activity studies indicated that anikasin’s mode of action is directly resulting from its physicochemical properties.
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