(2022)
Deciphering chemical mediators regulating specialized metabolism in a symbiotic cyanobacterium.
Angew Chem Int Ed 61(26),
e202204545.
Prof. Dr. Christian Hertweck
Biomolecular Chemistry · Head +49 3641 532-1101 christian.hertweck@leibniz-hki.deCurriculum vitae
Main Research Areas
- Investigation of biosynthetic pathways of the secondary metabolism of bacteria and fungi
- Use of enzymes and recombinant microorganisms for synthetic implementation
- Isolation and structural identification of natural products
- Molecular basis of fungus-bacteria-interactions
Professional Career
2008 | Rejection of professorship, Eidgenössische Technische Hochschule Zurich, Switzerland |
2008 – 2023 | Deputy Director at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (HKI) Jena, Germany |
2008 | Rejection of professorship, Technical University Munich, Germany |
Since 2006 | Head of Department of Biomolecular Chemistry, HKI Jena |
Since 2006 | Professor (W3) and chair of Natural Product Chemistry, Friedrich Schiller University Jena (FSU), Germany |
2006 | Habilitation (Venia legendi) in organic chemistry, FSU Jena |
2005 | Rejection of professorship (W3), Rheinische Friedrich Willhelms University of Bonn, Germany |
2005 | Acceptance of professorship (W3), FSU Jena |
2001– 2005 | Head of junior research group, HKI Jena |
1999 – 2000 | Research assistant, University of Washington, Seattle, USA, funded through a Feodor Lynen fellowship for postdocs (Alexander von Humboldt Foundation) |
1996 – 1999 | PhD, Friedrich Willhelms University Bonn and Max Planck Institute for Chemical Ecology, Jena, funded through a Max Planck doctoral fellowship |
1996 | Diploma in chemistry at the Friedrich Willhelms University Bonn, Germany |
Awards · Appointments · Scientific Activities
2015 | Member of the National Academy of Sciences Leopoldina |
2015 | Gottfried Wilhelm Leibniz Award |
2015 | David Gottlieb Memorial Lecture Award, University of Illinois |
2014 | Wilhelm Manchot-Research Professor |
Since 2013 | Member of the editorial board Bioorganic Chemistry |
Since 2012 | Editor, Chemistry & Biology |
Since 2012 | Member of the faculty of 1000 |
Since 2011 | Member of the editorial board, Organic and Biomolecular Chemistry |
Since 2011 | Member of the editorial board, Journal of Antibiotics |
2011 | NPR lecture award |
Since 2010 | Member of the editorial board, ChemBioChem |
2009 – 2012 | Member of the editorial board, Chemistry & Biology |
2006 | Research prize of the Dr. Otto Röhm-Memorial-Foundation |
Since 2005 | Member of the Association for General and Applied Microbiology (VAAM) |
2005 | DECHEMA award for natural product research |
2005 | Science award for life sciences and physics from the Beutenberg Campus Jena e.V. |
2005 | Thuringian research award (category: basic research) |
Since 2003 | Member of the programme committee, Natural Product Meeting, Irsee |
Since 2002 | Member of the DECHEMA Society for Chemical Engineering and Biotechnology |
Since 2001 | Member of the Gesellschaft Deutscher Chemiker (GDCh) |
Publications
(2022)
Assessment of bioactivity-modulating pseudo-ring formation in psilocin and related tryptamines.
ChemBioChem 23(13),
e202200183.
(2022)
An intramodular thioesterase domain catalyses chain release in the biosynthesis of a cytotoxic virulence factor.
RSC Chem Biol 3(9),
1121-1128.
(2022)
Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis.
Nat Prod Rep 39(1),
163-205.
(Review)
(2022)
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science 376(6600),
1471-1476.
(2022)
Peptide splicing is a prevalent biosynthetic strategy for installing β-amino acid pharmacophores
CellPress
[Epub ahead of print] (Review)
(2022)
Rapid screening of polyol polyketides from marine Dinoflagellates.
Anal Chem 94(41),
14205-14213.
(2022)
Proof-reading thioesterase boosts activity of engineered nonribosomal peptide synthetase.
ACS Chem Biol 17(9),
2382-2388.
(2022)
Toxin-producing endosymbionts shield pathogenic fungus against micropredators.
mBio 13(5),
e0144022.
(2022)
Reply to Oren et al., "New phylum names harmonize prokaryotic nomenclature".
mBio 13(5),
e0232322.
(Review)