Publications

Schäfer T, Haun F, Rupp B, Hoffmeister D (2025) Dissimilar reactions and enzymes for Psilocybin biosynthesis in inocybe and Psilocybe mushrooms. Angew Chem Int Ed 64(46), e202512017.
Schäfer T, Sherwood A, Kirkland T, Krüger T, Worbs J, Kniemeyer O, Gressler M, Hoffmeister D (2025) In vitro psilocybin synthesis by co-immobilized enzymes. Chem Eur J 31(29), e202501037.
Slot JC, Hoffmeister D (2025) Psychedelic fungi. Curr Biol 35(11), R513-R518.
Weiser S, Jung S, Bardl B, Kufs JE, Janevska S, Valiante V, Hoffmeister D, Regestein L (2025) Psilocybin production with genetically modified Aspergillus nidulans under pressurized conditions. Biotechnol Bioeng , 1-13.
Zschoche N, Schober S, Walther K, Chadeayne AR, Gressler M, Bartram S, O'Connor SE, Hoffmeister D (2025) Clade III synthases add cyclic and linear terpenoids to the Psilocybe metabolome. ChemBioChem 26(13), e202500167.
Büttner H, Rassbach J, Schultz C, Popp J, Gressler M, Hertweck C (2024) Beneficial soil fungus kills predatory nematodes with dehydropeptides translocating into the animal gut. J Am Chem Soc 146(50), 34702-34710.
Dellière S, Chauvin C, Wong SSW, Gressler M, Possetti V, Parente R, Fontaine T, Krüger T, Kniemeyer O, Bayry J, Carvalho A, Brakhage AA, Inforzato A, Latgé JP, Aimanianda V (2024) Interplay between host humoral pattern recognition molecules controls undue immuneresponses against Aspergillus fumigatus. Nat Commun 15(1), 6966.
Dörner S, Trottmann F, Jordan P, Bartels B, Rogge K, Werz O, Hertweck C, Hoffmeister D (2024) The fatal mushroom neurotoxin muscarine is released from a harmless phosphorylated precursor upon cellular injury. Angew Chem Int Ed 63(52), e202417220.
Hudspeth J, Rogge K, Dörner S, Müll M, Hoffmeister D, Rupp B, Werten S (2024) Methyl transfer in psilocybin biosynthesis. Nat Commun 15(1), 2709.
Hudspeth JD, Rogge K, Wagner T, Müll M, Hoffmeister D, Rupp B, Werten S (2024) The second methylation in Psilocybin biosynthesis is enabled by a hydrogen bonding network extending into the secondary sphere surrounding the methyltransferase active site. ChemBioChem 25(23), e202400497.