(2022)
The toll pathway mediates Drosophila resilience to Aspergillus mycotoxins through specific bomanins.
EMBO Rep 24(1),
e56036.
Prof. Dr. Axel A. Brakhage
Director Molecular and Applied Microbiology · Head of Department Transfer Group Antiinfectives · Acting head +49 3641 532-1001 axel.brakhage@leibniz-hki.deCurriculum vitae
Main Research Areas
- Infection biology of human pathogenic fungi
- Molecular biotechnology / synthetic biotechnology of microbial compounds
- Microbial communication
- Eukaryotic gene regulation / transcription factors
Professional Career
since 2005 | Scientific Director, Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) Jena |
since 2005 | Head of Department Molecular and Applied Microbiology, Leibniz-HKI Jena |
since 2004 | Professor (C4/W3) and chair in microbiology and molecular biology, Institute for Microbiology, Friedrich Schiller University Jena |
2001-2004 | Professor (C4) and chair in microbiology, Leibniz University Hanover |
1998-2001 | Professor (C3) in microbiology, Technical University Darmstadt |
1996 | Habilitation in microbiology, Ludwig-Maximilians-University Munich |
1992-1998 | Research assistant (C1), Institute for Genetics and Microbiology, Ludwig Maximilian University of Munich |
1990-1992 | Research assistant, The University of Sheffield, UK, funded through postdoc grants of the DFG |
1989-1990 | Group head, Biotechnology, BASF AG, Ludwigshafen |
1989 | Dr. rer. nat. in microbiology, „summa cum laude“ University Münster and Institut de Biologie Physico-Chimique (IBPC) Paris |
1985 | Studies in biology/chemistry, diploma in biology at the Westfälische Wilhelms-Universität Münster |
Awards · Appointments · Scientific Activities
2024 | Ferdinand Cohn-Medal of the German Society for Hygiene and Microbiology (DGHM) |
since 2020 | Vice President of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) |
since 2020 | Head of section 13 "Microbiology and Immunology" and Senator in the German National Academy of Sciences Leopoldina |
since 2020 | Board of Directors, Leibniz Center for Photonics in Infection Research (LPI) |
since 2020 | Founding member and Board of Directors "Incate" Incubator for Antibacterial Therapies in Europe |
since 2019 | Member of the scientific panel of the Leibniz Institute of Virology (LIV), Hamburg |
since 2019 | Member of the foundation board of the Leibniz Institute for Immunotherapy (LIT), Regensburg |
2019-2022 | Spokesperson of the Excellence Cluster "Balance of the Microverse" (DFG) |
since 2018 | Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Münster |
since 2017 | Member of the Steering Committee DZIF/TTU Novel Antibiotics |
since 2017 | Elected member of the American Academy of Microbiology |
since 2017 | Member of the scientific panel of the Robert Koch Foundation (RKS), Berlin |
since 2017 | Member of the scientific panel of the MRC Medical Mycology Centre, Exeter, UK |
since 2016 | Member of the Clusterboard RIS3 Thüringen |
since 2016 | Member of the scientific panel of the Max Planck Institute for Infection Biology (MPIIB), Berlin |
2016-2020 | Spokesperson of the Leibniz Research Cluster “Biotechnologie 2020+“ |
since 2015 | Elected member of the European Academy of Microbiology |
since 2015 | Honorary member of the Deutschsprachige Mykologische Gesellschaft e.V. (DMykG) |
2014 | Main Research Award of the German Society for Hygiene and Microbiology (DGHM) |
since 2013 | Spokesperson of the SFB/Transregio 124 FungiNet (DFG) |
2013-2020 | Deputy representative of the Leibniz-Research-Alliance Compounds and Biotechnology |
since 2013 | Board member of the research campus “InfectoGnostics” (BMBF) |
since 2012 | Spokesperson of the consortium “InfectControl 2020 – New Anti-infection Strategies – Science • Society • Economy” in the BMBF-programme “Zwanzig 20 – Partnership for Innovation” |
2012-2016 | Representative of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
2010-2012 | Board member of the Integriertes Forschungs- und Behandlungszentrum “Center for Sepsis Control and Care” (CSCC) at the University Hospital Jena |
2010-2018 | Authorised commissioner of the Leibniz Association for Biotechnology |
2010-2018 | Member of the scientific panel of the Helmholtz-Centre for Infection Research (HZI), Braunschweig |
2010-2018 | Member of the scientific panel of the Institute for Pharmaceutical Research (HIPS), Saarbrücken |
2010-2020 | Member of the scientific panel of the Research Centre Borstel, Borstel |
2010-2017 | Member of the scientific panel of the Leibniz Institute of Plant Biochemistry (IPB), Halle |
2009-2017 | Supervisory Board Leibniz-Institute DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig |
2009-2016 | Member of the scientific panel of the Research Center for Infectious Diseases (ZINF), Würzburg |
2009-2011 | President of the Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM) |
2008-2019 | Member of the university council (reappointment 2011+2015) at the Friedrich Schiller University Jena |
2008-2016 | Member of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
2008 | Appointed member of the Nationale Akademie der Wissenschaften, Leopoldina |
2007-2016 | Liaison Officer for scientific misconduct at the FSU Jena |
2007-2020 | Spokesperson of the excellence graduate school „Jena School for Microbial Communication” (JSMC) |
2006-2008 | Spokesperson of the graduate school "International Leibniz Research School (ILRS) for microbial and biomolecular interactions“ |
2006 | Heinz-Seeliger award for infection biology |
since 2005 | Scientific panel "Goettinger Center for Molecular Bio/Sciences" (GZMB), Georg-August-University Göttingen |
2005-2022 | Member of the Faculty Council of the Faculty of Biological Sciences, Friedrich Schiller University Jena |
2004-2010 | Representative of the DFG Priority Programme 1160 "Colonisation and Infection by Human-pathogenic Fungi" |
2003-2010 | Scientific panel „Center for Microbial Biotechnology“ DTU Copenhagen, Denmark |
2003-2009 | Member in the programme committee of the DFG Priority Programme 1152 "Evolution of Metabolic Diversity" |
2003-2004 | Dean, faculty biology, Leibniz-University Hanover |
2002-2006, 2009-2020 |
Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Würzburg |
since 1998 | Editor of several magazines |
since 1995 | Principal investigator in EU projects |
Publications
(2021)
Host-derived extracellular vesicles for antimicrobial defense.
microLife 2,
uqab003.
(Review)
(2021)
Carbon catabolite repression in filamentous fungi is regulated by phosphorylation of the transcription factor CreA.
mBio 12(1),
e03146-20.
(2021)
Dynamic optimization reveals alveolar epithelial cells as key mediators of host defense in invasive aspergillosis.
PLOS Comput Biol 17(12),
e1009645.
(2021)
Aspergillus metabolome database for mass spectrometry metabolomics.
J Fungi (Basel) 7(5),
387.
(2021)
Isolation and immunofluorescence staining of Aspergillus fumigatus conidia-containing phagolysosomes.
STAR Protoc 2(1),
100328.
(2021)
Bacterial cell wall-degrading enzymes induce basidiomycete natural product biosynthesis.
Environ Microbiol 23(8),
4360-4371.
(2021)
Bacterial marginolactones trigger formation of algal gloeocapsoids, protective aggregates on the verge of multicellularity.
Proc Natl Acad Sci U S A 118(45),
e2100892118.
(2021)
Chronic occupational mold exposure drives expansion of Aspergillus-reactive type 1 and type 2 T-helper cell responses.
J Fungi 7(9),
698.
(2021)
Development of a simple and robust whole blood assay with dual co-stimulation to quantify the release of T-cellular signature cytokines in response to Aspergillus fumigatus antigens.
J Fungi (Basel) 7(6),
462.