Dirk Hoffmeister

Pharmaceutical Microbiology · Head +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.de

Curriculum vitae

Main Research Areas

Biochemical and genetic basis of fungal natural product biosyntheses
Natural products of basidiomycetes and Ralstonia solanacearum
Microbial nonribosomal peptide synthetases

Professional Career

2014-	Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena
2009-2014	Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena
2007-2009	Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA
2008	Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg
2004-2007	Junior Group Leader, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg
2002-2004	Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship)
2002	Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg
1998	Diploma in biology at the Eberhard-Karls-University, Tübingen

Awards · Appointments · Scientific Activities

Since 2020	Head of the Institute for Pharmacy, FSU Jena
2016-2019	Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena
2013-2016	Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM).

Publications

Hudspeth J, Rogge K, Dörner S, Müll M, Hoffmeister D, Rupp B, Werten S (2024) Methyl transfer in psilocybin biosynthesis. Nat Commun 15(1), 2709.

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Schäfer T, Haun F, Gressler M, Spiteller P, Hoffmeister D (2024) Parallel evolution of Asco- and Basidiomycete O-Prenyltransferases. J Nat Prod 87(3), 576-582.

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Löhr NA, Rakhmanov M, Wurlitzer JM, Lackner G, Gressler M, Hoffmeister D (2023) Basidiomycete non-reducing polyketide synthases function independently of SAT domains. Fungal Biol Biotechnol 10(1), 17.

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Schäfer E, Seibold PS, Bartram S, Trottmann F, Hänsch V, Gressler M, Chadeayne A, Hertweck C, O'Connor S, Hoffmeister D (2023) A "Magic Mushroom" multi-product sesquiterpene synthase. ChemBioChem 24(21), e202300511.

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Seibold PS, Lawrinowitz S, Raztsou I, Gressler M, Arndt HD, Stallforth P, Hoffmeister D (2023) Bifurcate evolution of quinone synthetases in basidiomycetes. Fungal Biol Biotechnol 10(1), 14.

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Wein P, Dornblut K, Herkersdorf S, Krüger T, Molloy EM, Brakhage AA, Hoffmeister D, Hertweck C (2023) Bacterial secretion systems contribute to rapid tissue decay in button mushroom soft rot disease. mBio 14(4), e0078723.

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Yang YL, Zhou M, Yang L, Gressler M, Rassbach J, Wurlitzer JM, Zeng Y, Gao K, Hoffmeister D (2023) A mushroom P450-monooxygenase enables regio- and stereoselective biocatalytic synthesis of epoxycyclohexenones. Angew Chem Intl Ed 62(49), e202313817.

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Dörner S, Rogge K, Fricke J, Schäfer T, Wurlitzer JM, Gressler M, Pham DNK, Manke DR, Chadeayne AR, Hoffmeister D (2022) Genetic survey of Psilocybe natural products. ChemBioChem 23(14), e202200249.

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Ezediokpu MN, Krause K, Kunert M, Hoffmeister D, Boland W, Kothe E (2022) Ectomycorrhizal influence on the dynamics of sesquiterpene release by Tricholoma vaccinum. J Fungi (Basel) 8(6), 555.

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Kreuzenbeck NB, Seibel E, Schwitalla JW, Fricke J, Conlon BH, Schmidt S, Hammerbacher A, Köllner TG, Poulsen M, Hoffmeister D, Beemelmanns C (2022) Comparative genomic and metabolomic analysis of Termitomyces species provides insights into the terpenome of the fungal cultivar and the characteristic odor of the fungus garden of Macrotermes natalensis termites. mSystems 7(1), e0121421.

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