(2024)
Methyl transfer in psilocybin biosynthesis.
Nat Commun 15(1),
2709.
Dirk Hoffmeister
Pharmaceutical Microbiology · Head +49 3641 9-49850 dirk.hoffmeister@leibniz-hki.deCurriculum vitae
Main Research Areas
- Quinone synthetases and related enzymes
- Polyketide synthases of basidiomycetes
- Biosynthesis of psilocybin
- Natural products of the genus Psilocybe
Professional Career
| 2014- | Full Professor for Pharmaceutical Microbiology, FSU Jena and HKI Jena |
| 2009-2014 | Associate Professor for Pharmaceutical Biology, FSU Jena and head of the associated department Pharmaceutical Biology at the HKI Jena |
| 2007-2009 | Assistant Professor (tenure track) University of Minnesota, Saint Paul, MN, USA |
| 2008 | Habilitation in Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University Freiburg |
| 2004-2007 | Junior Group Leader, Institute for Pharmacy, Albert-Ludwigs-University, Freiburg |
| 2002-2004 | Postdoc, University of Wisconsin, Madison, WI, USA (DFG-fellowship) |
| 2002 | Dr. rer. nat., Faculty of Chemistry and Pharmacy, Albert-Ludwigs-University, Freiburg |
| 1998 | Diploma in biology at the Eberhard-Karls-University, Tübingen |
Awards · Appointments · Scientific Activities
| Since 2020 | Head of the Institute for Pharmacy, FSU Jena |
| 2016-2019 | Dean for Study Affairs in the Faculty of Biology and Pharmacy, FSU Jena |
| 2013-2016 | Scientific advisory board, Vereinigung für Allgemeine und Angewandte Mikrobiologie (VAAM). |
Publications
(2024)
From the forest floor to the lab: insights into the diversity and complexity of mushroom polyketide synthases.
Curr Opin Chem Biol 82,
102510.
(Review)
(2024)
Regioselective oxidative phenol coupling by a mushroom unspecific peroxygenase.
Angew Chem Int Ed 63(42),
e202407425.
(2024)
Parallel evolution of Asco- and Basidiomycete O-Prenyltransferases.
J Nat Prod 87(3),
576-582.
(2024)
Genetic regulation of L-tryptophan metabolism in Psilocybe mexicana supports psilocybin biosynthesis.
Fungal Biol Biotechnol 11(1),
4.
(2023)
Basidiomycete non-reducing polyketide synthases function independently of SAT domains.
Fungal Biol Biotechnol 10(1),
17.
(2023)
A "Magic Mushroom" multi-product sesquiterpene synthase.
ChemBioChem 24(21),
e202300511.
(2023)
Bifurcate evolution of quinone synthetases in basidiomycetes.
Fungal Biol Biotechnol 10(1),
14.
(2023)
Bacterial secretion systems contribute to rapid tissue decay in button mushroom soft rot disease.
mBio 14(4),
e0078723.
(2023)
A mushroom P450-monooxygenase enables regio- and stereoselective biocatalytic synthesis of epoxycyclohexenones.
Angew Chem Intl Ed 62(49),
e202313817.
