The map to the natural product treasure trove

Leibniz-HKI scientists develop a model of the evolution of biosynthetic pathways

| by Christine Vogler

Dr. Pierre Stallforth, principal investigator of the study, in the analytic laboratory. Source: Anna Schroll

Even small genetic modifications lead to a breathtaking variety of natural substances formed by bacteria. The team led by the Jena biochemist Pierre Stallforth investigated how the biosynthesis of natural substances changed during evolution. He published the results in the journal "Chemical Science" of the British "Royal Society of Chemistry". Understanding these mechanisms also means being able to detect specifically effective substances. For example, they could be used as urgently needed new antibiotics or cancer drugs.

Original publication

Götze S, Arp J, Lackner G, Zhang S, Kries H, Klapper M, García-Altares M, Willing K, Günther M, Stallforth P (2019) Structure Elucidation of the Syringafactin Lipopeptides Provides Insight in the Evolution of Nonribosomal Peptide Synthetases. Chem Sci 10, 10979-10990.


Johannes Arp
María García-Altares Pérez
Sebastian Götze
Markus Günther
Martin Klapper
Hajo Kries
Gerald Lackner
Pierre Stallforth
Karsten Willing
Shuaibing Zhang

Science communication & accreditation

Friederike Gawlik
Charlotte Fuchs


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