The map to the natural product treasure trove
Leibniz-HKI scientists develop a model of the evolution of biosynthetic pathways
Even small genetic modifications lead to a breathtaking variety of natural substances formed by bacteria. The team led by the Jena biochemist Pierre Stallforth investigated how the biosynthesis of natural substances changed during evolution. He published the results in the journal "Chemical Science" of the British "Royal Society of Chemistry". Understanding these mechanisms also means being able to detect specifically effective substances. For example, they could be used as urgently needed new antibiotics or cancer drugs.
Götze S, Arp J, Lackner G, Zhang S, Kries H, Klapper M, García-Altares M, Willing K, Günther M, Stallforth P (2019) Structure Elucidation of the Syringafactin Lipopeptides Provides Insight in the Evolution of Nonribosomal Peptide Synthetases. Chem Sci 10, 10979-10990.
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