Previous studies revealed the natural product myxochelin A to possess potent antitumour activity at non-cytotoxic concentrations. While its antiinvasive properties are possibly due to an inhibition of matrix metalloproteinases, the antileukemic effects of myxochelin A could be traced to an inhibition of human 5-lipoxygenase. These findings make myxochelin A an interesting model compound for pharmacological investigations. Here, we present a concise synthetic route for the preparation of myxochelin A, which only involves three steps.