Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes.

Magyar J, Cseresnyés Z, Rusznák Z, Sipos I, Szücs G, Kovács L (1995) Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes. Gen Physiol Biophys 14(3), 191-201.

Abstract

Membrane currents of ventricular cardiomyocytes isolated from control, diabetic and insulin-treated diabetic Wistar rats have been measured using the whole cell configuration of the patch-clamp technique. Insulin restored the density of the 4-aminopyridine-sensitive early transient component of the calcium-independent outward potassium currents which decreased in diabetes. The inactivation rate of the transients increased in diabetes and was normalised by insulin. The late 4-aminopyridine-insensitive component of the outward currents showed the same diabetes- and insulin-related changes. This current could reflect the activation of the delayed rectifier channels although pharmacological identification of this component could not be achieved.

Leibniz-HKI-Authors

Zoltán Cseresnyés

Identifier

PMID: 8586253