A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.

Arndt B, Janevska S, Schmid R, Hübner F, Tudzynski B, Humpf HU (2017) A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi. Chembiochem 18(10), 899-904.

Abstract

The range of secondary metabolites (SMs) produced by the rice pathogen Fusarium fujikuroi is quite broad. Several polyketides, nonribosomal peptides and terpenes have been identified. However, no products of dimethylallyltryptophan synthases (DMATSs) have been elucidated, although two putative DMATS genes are present in the F. fujikuroi genome. In this study, the in vivo product derived from one of the DMATSs (DMATS1, FFUJ_09179) was identified with the help of the software MZmine 2. Detailed structure elucidation showed that this metabolite is a reversely N-prenylated tryptophan with a rare form of prenylation. Further identified products probably resulted from side reactions of DMATS1. The genes adjacent to DMATS1 were analyzed; this showed no influence on the biosynthesis of the product.

Leibniz-HKI-Authors

Slavica Janevska

Identifier

doi: 10.1002/cbic.201600691

PMID: 28295904