Polyhalogenation of isoflavonoids by the termite-associated Actinomadura sp. RB99.

Rak Lee S, Schalk F, Schwitalla JW, Benndorf R, Vollmers J, Kaster AK, de Beer ZW, Park M, Ahn MJ, Jung WH, Beemelmanns C, Kim KH (2020) Polyhalogenation of isoflavonoids by the termite-associated Actinomadura sp. RB99. J Nat Prod 83(10), 3102-3110.

Abstract

Based on high-resolution tandem mass spectrometry (HR-MS2) and global natural products social molecular networking (GNPS), we found that plant-derived daidzein and genistein derivatives are polyhalogenated by termite-associated Actinomadura species RB99. MS-guided purification from extracts of bacteria grown under optimized conditions led to the isolation of eight polychlorinated isoflavones, including six unreported derivatives, and seven novel polybrominated derivatives, two of which showed antimicrobial activity.

Leibniz-HKI-Authors

Christine Beemelmanns
René Benndorf
Jan Schwitalla
Felix Schalk

Identifier

doi: 10.1021/acs.jnatprod.0c00676

PMID: 32946237