To sense or not to sense, Paneth cell regulation of mucosal immunity.

Weis S, King IL, Vivas W (2024) To sense or not to sense, Paneth cell regulation of mucosal immunity. Cell Host Microbe 32(10), 1648-1650.

Abstract

Paneth cells located within intestinal crypts support epithelial stem cells and immunity through growth factors and antimicrobial peptides. In this issue of Cell Host & Microbe, Wallaeys et al. report that TNF sensing by Paneth cells disrupts the unfolded protein response and decreases antimicrobial peptides, causing bacterial translocation and sepsis.

Leibniz-HKI-Authors

Wolfgang Vivas
Sebastian Weis

Identifier

doi: 10.1016/j.chom.2024.09.005

PMID: 39389028