Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification.

Scherlach K, Nützmann HW, Schroeckh V, Dahse HM, Brakhage AA, Hertweck C (2011) Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed 50(42), 9843-9847.

Abstract

What makes a fungus blush? The deletion of a gene that is required for global protein N-acetylation triggers the production of unprecedented metabolites in Aspergillus nidulans. The pronounced red pigmentation of the engineered mutant is caused by pheofungins (benzothiazinone chromophores), the biogenesis of which is strikingly similar to those of pheomelanins found in red bird feathers and hair of Celtic origin.

Leibniz-HKI-Authors

Axel A. Brakhage
Christian Hertweck
Volker Schroeckh
Hans-Martin Dahse
Kirstin Scherlach
Hans W. Nützmann

Identifier

doi: 10.1002/anie.201104488

PMID: 21913294