Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus.

Scherlach K, Partida-Martinez LP, Dahse HM, Hertweck C (2006) Antimitotic rhizoxin derivatives from a cultured bacterial endosymbiont of the rice pathogenic fungus Rhizopus microsporus. J Am Chem Soc 128(35), 11529-11536.

Abstract

The potent antimitotic polyketide macrolide rhizoxin, the causal agent of rice seedling blight, is not produced by the fungus Rhizopus microsporus, as has been believed for over two decades, but by endosymbiotic bacteria that reside within the fungal mycelium. Here we report the successful isolation and large-scale fermentation of the bacterial endosymbiont (

Leibniz-HKI-Authors

Christian Hertweck
Hans-Martin Dahse
Kirstin Scherlach

Identifier

PMID: 16939276