Phagosome Biology and Engineering

Phagocytosis serves as a crucial mechanism of the innate immune system for pathogen clearance, antigen presentation to lymphocytes as connecting to adaptive immune responses, and the maintenance of cellular homeostasis. However, human fungal pathogens can interfere with the progress of phagocytosis, hindering phagosome maturation and initiating the infection process. We are interested in how fungal pathogens escape from phagosomal killing and the underlying molecular mechanisms.