JenXplor enables the automation of assays for the discovery of new antiinfectives. The robotic-platform contains three modules:

  • PhenXplor for phenotypical experiments
  • BioXplor for molecular biology experiments
  • ChemXplor for pharmacological and biochemical experiments

Automating repetitive experiments increases throughput and minimizes errors that can occur during manual work.

ChemXplor and BioXplor are connected and includes the following devices:

  • Liquid Handling Systems: CyBio FeliX (Analytik Jena), TEMPEST Liquid Dispenser (Formulatrix)
  • Sealing and Opening of Microtiter Plates: a4S Automatic Roll Heat Sealer (Azenta), Peeler XPeel (Azenta), Decapping Station (Analytik Jena)
  • Centrifuge: HiG 4 Automated Centrifuge (BioNex Solutions Inc.)
  • Barcode Printer: CyBio QuadPrint HQ-x (Analytik Jena)
  • PCR: qTower3 auto and TRobot II (Analytik Jena)
  • Colony Picker: K6-3 Colony Picker System (kbiosystems)
  • Reader: BioTek Synergy Neo 2 (Agilent)
  • Shakers: BioShake Q1, BioShake 3000-T elm, and ColdPlate slim (QInstruments)
  • Incubators: Cytomat 2 (Thermo Fisher)

PhenXplor is housed within a biological safety cabinet of Biosafety Level 2, allowing for bioactivity testing with Risk Group 2 pathogens. This module primarily conducts microbiological assays and has the capability for imaging readouts through a high-throughput microscope. The PhenXplor includes the following devices:

  • Liquid Handling Systems: CyBio FeliX (Analytik Jena) and BioTek EL406 Washer Dispenser (Agilent)
  • Sealing and opening of microtiter plates: Decapping Station (Analytik Jena)
  • Incubators: Cytomat 2 and Cytomat 5 (Thermo Fisher)
  • High-Throughput Confocal Microscope: BioTek Cytation 10 (Agilent)