Ni el al publishing in Advanced Science and made it to the Back Cover of the Issue (16-2021)

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New therapeutics Options for the Treatment of Diabetes

In the article appearing in Ad Sci, Huating Li, Gianni Panagiotou, Weiping Jia, and co-workers demonstrate lean patients with type 2 diabetes have distinct gut microbiota and bile acid profiles. The “Magician” Akkermansia muciniphila connects the gut to pancreas and liver by modulating 3β-chenodeoxycholic acid and fibroblast growth factor 19, which sheds light on new therapeutic options for the prevention or treatment of diabetes.

Original publication:

Zhang J, Ni Y, Qian L, Fang Q, Zheng T, Zhang M, Gao Q, Zhang Y, Ni J, Hou X, Bao Y, Kovatcheva-Datchary P, Xu A, Li H, Panagiotou G, Jia W. Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes. Adv Sci (Weinh). 2021 Aug;8(16):e2100536. DOI