High-yield production of coenzyme F420 in Escherichia coli

Metabolic Engineering

| by Gerald Lackner

Coenzyme F420 is a small "helper" molecule involved in antibiotics biosynthesis and resistance. It also promises interesting applications in biocatalysis. However, chemical synthesis of the coenzyme is cumbersome and production in microbes sufferes from low yields. In our new publication, we achieved  convenient high-yield production of the coenzyme in the model organism Escherichia coli by metabolic engineering. For more details, check out the original publication (open access) here: