(2023)
The lipid raft-associated protein stomatin is required for accumulation of dectin-1 in the phagosomal membrane and for full activity of macrophages against Aspergillus fumigatus.
mSphere 8(8),
e0052322.
Prof. Dr. Axel A. Brakhage
Director Molecular and Applied Microbiology · Head of Department Transfer Group Anti-infectives · Acting head +49 3641 532-1001 axel.brakhage@leibniz-hki.deCurriculum vitae
Main Research Areas
- Infection biology of human pathogenic fungi
- Molecular biotechnology / synthetic biotechnology of microbial compounds
- Microbial communication
- Eukaryotic gene regulation / transcription factors
Professional Career
| since 2005 | Scientific Director, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI) Jena |
| since 2005 | Head of Department Molecular and Applied Microbiology, HKI Jena |
| since 2004 | Professor (C4/W3) and chair in microbiology and molecular biology, Institute for Microbiology, FSU Jena |
| 2000-2004 | Professor (C4) and chair in microbiology, Leibniz University Hanover |
| 1998-2001 | Professor (C3) in microbiology, Technical University Darmstadt |
| 1996 | Habilitation in microbiology, Ludwig-Maximilians-University Munich |
| 1992-1998 | Research assistant (C1), Institute for Genetics and Microbiology, Ludwig-Maximilians-University Munich |
| 1990-1992 | Research assistant, The University of Sheffield, UK, funded through postdoc grants of the DFG |
| 1989-1990 | Group head, Biotechnology, BASF AG, Ludwigshafen |
| 1989 | Dr. rer. nat. in microbiology, „summa cum laude“ University Münster and Institut de Biologie Physico-Chimique (IBPC) Paris |
| 1985 | Studies in biology/chemistry, diploma in biology at the Westfälische Wilhelms-Universität Münster |
Awards · Appointments · Scientific Activities
| since 2020 | Vice President of the DFG |
| since 2020 | Head of section 13 "Microbiology and Immunology" and Senator in the German National Academy of Sciences Leopoldina |
| since 2019 | Spokesperson of the Excellence Cluster "Balance of the Microverse" |
| since 2019 | Member of the foundation board of the Foundation Regensburg Center for Interventional Immunology (RCI), Regensburg |
| since 2019 | Member of the scientific panel of the Heinrich-Pette Institute (HPI), Hamburg |
| since 2018 | Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Münster |
| since 2017 | Member of the Steering Committee DZIF/TTU |
| since 2017 | Elected member of the American Academy of Microbiology |
| since 2017 | Member of the scientific panel of the Robert Koch Foundation (RKS), Berlin |
| since 2017 | Member of the scientific panel of the MRC Medical Mycology Centre, Exeter, UK |
| since 2016 | Member of the Clusterboard RIS3 Thüringen |
| since 2016 | Member of the scientific panel of the Max Planck Institute for Infection Biology (MPIIB), Berlin |
| since 2016 | Spokesperson of the Leibniz Research Cluster “Biotechnologie 2020+“ |
| since 2015 | Elected member of the European Academy of Microbiology |
| since 2015 | Honorary member of the DMykG |
| 2014 | Main Research Award of the German Society for Hygiene and Microbiology (DGHM) |
| since 2013 | Spokesperson of the SFB/Transregio 124 FungiNet (DFG) |
| since 2013 | Deputy representative of the Leibniz-Research-Alliance Compounds and Biotechnology |
| since 2013 | Board member of the research campus “InfectoGnostics” (BMBF) |
| since 2012 | Spokesperson of the consortium “InfectControl 2020 – New Anti-infection Strategies – Science • Society • Economy” in the BMBF-programme “Zwanzig 20 – Partnership for Innovation” |
| 2012-2016 | Representative of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
| 2010-2012 | Board member of the Integriertes Forschungs- und Behandlungszentrum “Center for Sepsis Control and Care” (CSCC) at the University Hospital Jena |
| 2010-2016 | Spokesperson (and authorised commissioner) of the Leibniz Research Cluster “Biotechnologie 2020+“ |
| since 2010 | Member of the scientific panel of the Helmholtz-Centre for Infection Research (HZI), Braunschweig |
| 2010-2018 | Member of the scientific panel of the –Institute for Pharmaceutical Research (HIPS), Saarbrücken |
| 2010-2020 | Member of the scientific panel of the Research Centre Borstel, Borstel |
| 2010-2017 | Member of the scientific panel of the Leibniz Institute of Plant Biochemistry (IPB), Halle |
| 2009-2017 | Supervisory Board Leibniz-Institute DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig |
| 2009-2016 | Member of the scientific panel of the Research Center for Infectious Diseases (ZINF), Würzburg |
| 2009-2011 | President of the Vereinigung für Allgemeine und Angewandte Mikrobiologie |
| 2008-2019 | Member of the university council (reappointment 2011+2015) at the Friedrich-Schiller-University Jena |
| 2008-2016 | Member of the DFG-Professional Council 204 Microbiology, Immunology, Virology |
| 2008 | Appointed member of the Nationale Akademie der Wissenschaften, Leopoldina |
| 2007-2016 | Liaison Officer for scientific misconduct at the FSU Jena |
| since 2007 | Spokesperson of the excellence graduated school „Jena School for Microbial Communication” |
| 2006-2008 | Spokesperson of the graduate school "International Leibniz Research School (ILRS) for microbial and biomolecular interactions“ |
| 2006 | Heinz-Seeliger award for infection biology |
| since 2005 | Scientific panel "Goettinger Center for Molecular Bio/Sciences (GZMB)", Georg-August-University Göttingen |
| since 2005 | Member of the Faculty Council of the Faculty of Biological Sciences, FSU Jena |
| 2004-2010 | Representative of the DFG priority programme 1160 "colonisation and infection through human pathogenic fungi" |
| 2003-2010 | Scientific panel „Center for Microbial Biotechnology“ DTU Copenhagen, Denmark |
| 2003-2009 | Member in the programme committee of the DFG priority programme 1152 "Evolution of Metabolic Diversity" |
| 2003-2004 | Dean, faculty biology, Leibniz-University Hanover |
| 2002-2006, 2009-2020 |
Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Würzburg |
| since 1998 | Editor of several magazines |
| since 1995 | Principal investigator in EU projects |
Publications
(2023)
Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway.
Cell Host Microbe 31(3),
373-388.
(2023)
Polymer-based particles against pathogenic fungi: A non-uptake delivery of compounds.
Biomater Adv 146,
213300.
(2023)
Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis.
J Clin Invest ,
e161593.
(2023)
Functional modulation of chemical mediators in microbial communities.
Trends Biochem Sci 48(1),
71-81.
(Review)
(2022)
INCATE: a partnership to boost the antibiotic pipeline.
Nat Rev Drug Discov 21(9),
621-622.
(2022)
Prediction and validation of host-pathogen interactions by a versatile inference approach using Aspergillus fumigatus as a case study.
Comput Struct Biotechnol J 20,
4225-4237.
(2022)
Impaired amino acid uptake leads to global metabolic imbalance of Candida albicans biofilms.
NPJ Biofilms Microbiomes 8(1),
78.
(2022)
Candida albicans SR-like protein kinases regulate different cellular processes: Sky1 is involved in control of ion homeostasis, while Sky2 is important for dipeptide utilization.
Front Cell Infect Microbiol 12,
850531.
(2022)
Targeting of phagolysosomes containing conidia of the human pathogenic fungus Aspergillus fumigatus with polymeric particles.
Appl Microbiol Biotechnol ,
1-16.
