Curriculum vitae

Main Research Areas
  • Infection biology of human pathogenic fungi
  • Molecular biotechnology / synthetic biotechnology of microbial compounds
  • Microbial communication
  • Eukaryotic gene regulation / transcription factors
Professional Career
since 2005  Scientific Director, Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll-Institute (HKI) Jena
since 2005 Head of Department Molecular and Applied Microbiology, HKI Jena
since 2004 Professor (C4/W3) and chair in microbiology and molecular biology, Institute for Microbiology, FSU Jena
2000-2004 Professor (C4) and chair in microbiology, Leibniz University Hanover
1998-2001 Professor (C3) in microbiology, Technical University Darmstadt
1996 Habilitation in microbiology, Ludwig-Maximilians-University Munich
1992-1998 Research assistant (C1), Institute for Genetics and Microbiology, Ludwig-Maximilians-University Munich
1990-1992 Research assistant, The University of Sheffield, UK, funded through postdoc grants of the DFG
1989-1990 Group head, Biotechnology, BASF AG, Ludwigshafen
1989 Dr. rer. nat. in microbiology, „summa cum laude“ University Münster and Institut de Biologie Physico-Chimique (IBPC) Paris
1985 Studies in biology/chemistry, diploma in biology at the Westfälische Wilhelms-Universität Münster
Awards · Appointments · Scientific Activities
since 2020  Vice President of the DFG
since 2020 Head of section 13 "Microbiology and Immunology" and Senator in the German National Academy of Sciences Leopoldina
since 2019 Spokesperson of the Excellence Cluster "Balance of the Microverse"
since 2019 Member of the foundation board of the Foundation Regensburg Center for Interventional Immunology (RCI), Regensburg
since 2019 Member of the scientific panel of the Heinrich-Pette Institute (HPI), Hamburg
since 2018 Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Münster
since 2017 Member of the Steering Committee DZIF/TTU
since 2017 Elected member of the American Academy of Microbiology
since 2017 Member of the scientific panel of the Robert Koch Foundation (RKS), Berlin
since 2017 Member of the scientific panel of the MRC Medical Mycology Centre, Exeter, UK
since 2016 Member of the Clusterboard RIS3 Thüringen
since 2016 Member of the scientific panel of the Max Planck Institute for Infection Biology (MPIIB), Berlin
since 2016 Spokesperson of the Leibniz Research Cluster “Biotechnologie 2020+“
since 2015 Elected member of the European Academy of Microbiology
since 2015 Honorary member of the DMykG
2014 Main Research Award of the German Society for Hygiene and Microbiology (DGHM)
since 2013 Spokesperson of the SFB/Transregio 124 FungiNet (DFG)
since 2013 Deputy representative of the Leibniz-Research-Alliance Compounds and Biotechnology
since 2013 Board member of the research campus “InfectoGnostics” (BMBF)
since 2012 Spokesperson of the consortium “InfectControl 2020 – New Anti-infection Strategies – Science • Society • Economy” in the BMBF-programme “Zwanzig 20 – Partnership for Innovation”
2012-2016 Representative of the DFG-Professional Council 204 Microbiology, Immunology, Virology
2010-2012 Board member of the Integriertes Forschungs- und Behandlungszentrum “Center for Sepsis Control and Care” (CSCC) at the University Hospital Jena
2010-2016 Spokesperson (and authorised commissioner) of the Leibniz Research Cluster “Biotechnologie 2020+“
since 2010 Member of the scientific panel of the Helmholtz-Centre for Infection Research (HZI), Braunschweig
2010-2018 Member of the scientific panel of the –Institute for Pharmaceutical Research (HIPS), Saarbrücken
2010-2020 Member of the scientific panel of the Research Centre Borstel, Borstel
2010-2017 Member of the scientific panel of the Leibniz Institute of Plant Biochemistry (IPB), Halle
2009-2017 Supervisory Board Leibniz-Institute DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig
2009-2016 Member of the scientific panel of the Research Center for Infectious Diseases (ZINF), Würzburg
2009-2011 President of the Vereinigung für Allgemeine und Angewandte Mikrobiologie
2008-2019 Member of the university council (reappointment 2011+2015) at the Friedrich-Schiller-University Jena
2008-2016 Member of the DFG-Professional Council 204 Microbiology, Immunology, Virology
2008 Appointed member of the Nationale Akademie der Wissenschaften, Leopoldina
2007-2016 Liaison Officer for scientific misconduct at the FSU Jena
since 2007 Spokesperson of the excellence graduated school „Jena School for Microbial Communication”
2006-2008 Spokesperson of the graduate school "International Leibniz Research School (ILRS) for microbial and biomolecular interactions“
2006 Heinz-Seeliger award for infection biology
since 2005 Scientific panel "Goettinger Center for Molecular Bio/Sciences (GZMB)", Georg-August-University Göttingen
since 2005 Member of the Faculty Council of the Faculty of Biological Sciences, FSU Jena
2004-2010 Representative of the DFG priority programme 1160 "colonisation and infection through human pathogenic fungi"
2003-2010 Scientific panel „Center for Microbial Biotechnology“ DTU Copenhagen, Denmark
2003-2009 Member in the programme committee of the DFG priority programme 1152 "Evolution of Metabolic Diversity"
2003-2004 Dean, faculty biology, Leibniz-University Hanover
2002-2006,
2009-2020
Member of the scientific panel of the Interdisciplinary Center for Clinical Research (IZKF), Würzburg
since 1998 Editor of several magazines
since 1995 Principal investigator in EU projects

Publications

Satish S, Jiménez-Ortigosa C, Zhao Y, Lee MH, Dolgov E, Krüger T, Park S, Denning DW, Kniemeyer O, Brakhage AA, Perlin DS (2019) Stress-induced changes in the lipid microenvironment of β-(1,3)-d-glucan synthase cause clinically important Echinocandin resistance in Aspergillus fumigatus. mBio 10(3), e00779-19.
Shekhova E, Ivanova L, Krüger T, Stroe MC, Macheleidt J, Kniemeyer O, Brakhage AA (2019) Redox proteomic analysis reveals oxidative modifications of proteins by increased levels of intracellular reactive oxygen species during hypoxia adaptation of Aspergillus fumigatus. Proteomics 19(5), e1800339.
Stroe MC, Netzker T, Schroeckh V, Hanf B, Brakhage AA (2019) Microbial co-cultures as source of novel drugs for infections. In: Elsevier Science (ed.) Comprehensive Natural Products III: Chemistry and Biology 3, pp. Chapter 30015. Elsevier. (Review)
Wondraczek L, Pohnert G, Schacher FH, Köhler A, Gottschaldt M, Schubert US, Küsel K, Brakhage AA (2019) Artificial microbial arenas: Materials for observing and manipulating microbial consortia. Adv Mater 31(24), e1900284. (Review)
Zhao C, Fraczek M, Dineen L, Lebedinec R, Macheleidt J, Heinekamp T, Delneri D, Bowyer P, Brakhage AA, Bromley M (2019) High throughput gene replacement in Aspergillus fumigatus. Curr Protoc Microbiol 54(1), e88.
Arp J, Götze S, Mukherji R, Mattern DJ, Garcia-Altares M, Klapper M, Brock DA, Brakhage AA, Strassmann JE, Queller DC, Bardl B, Willing K, Peschel G, Stallforth P (2018) Synergistic activity of co-secreted natural products from amoebae-associated bacteria. Proc Natl Acad Sci USA 115(15), 3758-3763.
Conrad T*, Kniemeyer O, Henkel SG, Krüger T, Mattern DJ, Valiante V, Guthke R, Jacobsen ID, Brakhage AA, Vlaic S, Linde J (2018) Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin. BMC Syst Biol 12(1), 88.
Dasari P, Shopova IA, Stroe M, Wartenberg D, Dahse HM, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF (2018) Aspf2 from Aspergillus fumigatus recruits human immune regulators for immune evasion and cell damage. Front Immunol 9, 1635.
Dijck PV, Sjollema J, Cammue BP, Lagrou K, Berman J, d'Enfert C, Andes DR, Arendrup MC, Brakhage AA, Calderone R, Cantón E, Coenye T, Cos P, Cowen LE, Edgerton M, Espinel-Ingroff A, Filler SG, Ghannoum M, Gow NAR, Haas H, Jabra-Rizk MA, Johnson EM, Lockhart SR, Lopez-Ribot JL, Maertens J, Munro CA, Nett JE, Nobile CJ, Pfaller MA, Ramage G, Sanglard D, Sanguinetti M, Spriet I, Verweij PE, Warris A, Wauters J, Yeaman MR, Zaat SAJ, Thevissen K (2018) Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms. Microb Cell 5(7), 300-326. (Review)
Fischer J, Müller SY, Netzker T, Jäger N, Gacek-Matthews A, Scherlach K, Stroe MC, García-Altares M, Pezzini F, Schoeler H, Reichelt M, Gershenzon, Krespach MK, Shelest E, Schroeckh V, Valiante V, Heinzel T, Hertweck C, Strauss J, Brakhage AA (2018) Chromatin mapping identifies BasR, a key regulator of bacteria-triggered production of fungal secondary metabolites. eLife 7, e40969.